Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2914630 | 1.00 | PKM (0.42) | PKMALOX15CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL29511426 | 0.83 | CYP4F2 (0.44) | PKMALOX15CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL2918118 | 0.81 | PKM (0.41) | PKMALOX15CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL2918114 | 0.81 | PKM (0.41) | PKMALOX15CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL2915795 | 0.80 | PKM (0.43) | PKMALOX15CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL28625143 | 0.78 | PKM (0.39) | PKMALOX15CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL9040519 | 0.77 | PKM (0.48) | PKMALOX15CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL7375510 | 0.77 | ALDH1A1 (0.37) | PKMALOX15CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL3576477 | 0.77 | — | — | |
| SCHEMBL13112959 | 0.75 | HCAR2 (0.41) | PKMALOX15CYP4F2CYP4A11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10364208-B2 | Oxidative coupling of aryl boron reagents with SP3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2019-07-30 | — | — | US | disclosed |
| US-20180186721-A1 | OXIDATIVE COUPLING OF ARYL BORON REAGENTS WITH SP3-CARBON NUCLEOPHILES, AND AMBIENT DECARBOXYLATIVE ARYLATION OF MALONATE HALF-ESTERS VIA OXIDATIVE CATALYSIS | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2018-07-05 | — | — | US | disclosed |
| EP-2225382-B1 | NEW MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS | BASF SE (DE) | 2016-11-09 | — | — | EP | disclosed |
| US-20150147800-A1 | MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS | BASF SE (DE) | 2015-05-28 | — | — | US | disclosed |
| US-8951750-B2 | Malonate decarboxylases for industrial applications | BASF SE (DE) | 2015-02-10 | — | — | US | disclosed |
| EP-2565273-A1 | New malonate decarboxylases for industrial applications | BASF SE (DE) | 2013-03-06 | — | — | EP | disclosed |
| EP-2565274-A1 | New malonate decarboxylases for industrial applications | BASF SE (DE) | 2013-03-06 | — | — | EP | disclosed |
| US-20100311037-A1 | MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS | BASF SE (DE) | 2010-12-09 | — | — | US | disclosed |
| EP-2225382-A2 | NEW MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS | BASF SE (DE) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009068308-A2 | NEW MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS | BASF SE (DE) | 2009-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10364208-B2 | Oxidative coupling of aryl boron reagents with SP3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis | SOD1, AOC3, CBR3 | PKM 2303/4885ALOX15 338/4885CYP4F2 190/4885 |
| US-20100311037-A1 | MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS | ME1, AMD1, GMDS | PKM 617/4885ALOX15 1179/4885CYP4F2 2388/4885 |
| US-20180186721-A1 | OXIDATIVE COUPLING OF ARYL BORON REAGENTS WITH SP3-CARBON NUCLEOPHILES, AND AMBIENT DECARBOXYLATIVE ARYLATION OF MALONATE HALF-ESTERS VIA OXIDATIVE CATALYSIS | SOD1, AOC3, CBR3 | PKM 2303/4885ALOX15 338/4885CYP4F2 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.