Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 5/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.34 |
| ▸ | PSMB2 | P49721 | 5/20 | 0.34 |
| ▸ | PSMB11 | A5LHX3 | 4/20 | 0.34 |
| ▸ | PSMA7 | O14818 | 4/20 | 0.34 |
| ▸ | PSMA1 | P25786 | 4/20 | 0.34 |
| ▸ | PSMA2 | P25787 | 4/20 | 0.34 |
| ▸ | PSMA3 | P25788 | 4/20 | 0.34 |
| ▸ | PSMA4 | P25789 | 4/20 | 0.34 |
| ▸ | PSMB8 | P28062 | 4/20 | 0.34 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.34 |
| ▸ | PSMA5 | P28066 | 4/20 | 0.34 |
| ▸ | PSMB4 | P28070 | 4/20 | 0.34 |
| ▸ | PSMB6 | P28072 | 4/20 | 0.34 |
| ▸ | PSMB10 | P40306 | 4/20 | 0.34 |
| ▸ | PSMB3 | P49720 | 4/20 | 0.34 |
| ▸ | PSMA6 | P60900 | 4/20 | 0.34 |
| ▸ | PSMA8 | Q8TAA3 | 4/20 | 0.34 |
| ▸ | PSMB7 | Q99436 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10337081 | 0.89 | PSMB11 (0.34) | PSMB1PSMB5PSMB2PSMB11PSMA7 | |
| SCHEMBL3401832 | 0.87 | MAPT (0.30) | — | |
| SCHEMBL3015139 | 0.82 | PSMB1 (0.36) | PSMB1PSMB5PSMB2PSMB11PSMA7 | |
| SCHEMBL25946829 | 0.80 | PSMB1 (0.35) | PSMB1PSMB5PSMB2PSMB11PSMA7 | |
| SCHEMBL9182934 | 0.80 | PSMB1 (0.35) | PSMB1PSMB5PSMB2PSMB11PSMA7 | |
| SCHEMBL8037299 | 0.80 | SLC1A2 (0.37) | PSMB1PSMB5PSMB2PSMB11PSMA7 | |
| SCHEMBL22279577 | 0.80 | PSMB1 (0.33) | PSMB1PSMB5PSMB2PSMB11PSMA7 | |
| SCHEMBL25660383 | 0.80 | SLC1A2 (0.37) | PSMB1PSMB5PSMB2PSMB11PSMA7 | |
| SCHEMBL10835668 | 0.77 | MAPT (0.34) | PSMB1PSMB5PSMB2PSMB11PSMA7 | |
| SCHEMBL15973796 | 0.77 | THRB (0.39) | PSMB1PSMB5PSMB2PSMB11PSMA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11028052-B2 | Compounds useful as modulators of TRPM8 | FIRMENICH INCORPORATED (US) | 2021-06-08 | — | — | US | disclosed |
| EP-3461816-B1 | FIVE-MEMBERED HETEROCYLIC COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED (US) | 2021-03-24 | — | — | EP | disclosed |
| US-10421727-B2 | Compounds useful as modulators of TRPM8 | FIRMENICH INCORPORATED (US) | 2019-09-24 | — | — | US | disclosed |
| EP-3461816-A1 | FIVE-MEMBERED HETEROCYLIC COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2019-04-03 | — | — | EP | disclosed |
| US-20170369447-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2017-12-28 | — | — | US | disclosed |
| US-9840471-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| EP-2225382-B1 | NEW MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS | BASF SE (DE) | 2016-11-09 | — | — | EP | disclosed |
| US-20150376136-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. | 2015-12-31 | — | — | US | disclosed |
| EP-2958897-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2015-12-30 | — | — | EP | disclosed |
| US-20150147800-A1 | MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS | BASF SE (DE) | 2015-05-28 | — | — | US | disclosed |
| US-8951750-B2 | Malonate decarboxylases for industrial applications | BASF SE (DE) | 2015-02-10 | — | — | US | disclosed |
| WO-2014130582-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2014-08-28 | — | — | WO | disclosed |
| EP-2565273-A1 | New malonate decarboxylases for industrial applications | BASF SE (DE) | 2013-03-06 | — | — | EP | disclosed |
| EP-2565274-A1 | New malonate decarboxylases for industrial applications | BASF SE (DE) | 2013-03-06 | — | — | EP | disclosed |
| US-20100311037-A1 | MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS | BASF SE (DE) | 2010-12-09 | — | — | US | disclosed |
| EP-2225382-A2 | NEW MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS | BASF SE (DE) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009068308-A2 | NEW MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS | BASF SE (DE) | 2009-06-04 | — | — | WO | disclosed |
| US-6620954-B1 | Alkylation catalysts such as 1-(-(2-diphenylphosphino)-ferrocenyl)ethyl acetamide, used for resolution of racemic mixtures | EASTMAN CHEMICAL COMPANY | 2003-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10421727-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPA1 | PSMB1 3526/4885PSMB5 2649/4885PSMB2 3138/4885 |
| US-20150376136-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPA1 | PSMB1 3526/4885PSMB5 2649/4885PSMB2 3138/4885 |
| US-20100311037-A1 | MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS | ME1, AMD1, GMDS | PSMB1 3083/4885PSMB5 2329/4885PSMB2 3515/4885 |
| US-20170369447-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPA1 | PSMB1 3526/4885PSMB5 2649/4885PSMB2 3138/4885 |
| US-11028052-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPA1 | PSMB1 3526/4885PSMB5 2649/4885PSMB2 3138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.