Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.44 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27571172 | 1.00 | NPSR1 (0.46) | NPSR1UTS2RGPR88SLC2A1TNF | |
| SCHEMBL28821222 | 0.85 | TSHR (0.42) | UTS2RLMNAALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL28995697 | 0.85 | RAB9A (0.40) | UTS2RTNFMMP1MMP2MMP3 | |
| SCHEMBL27674502 | 0.84 | LMNA (0.39) | MMP1MMP3LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL28404198 | 0.84 | KMT2A (0.43) | LMNAALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL27674503 | 0.84 | LMNA (0.39) | MMP1MMP3LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL28862367 | 0.84 | MAPT (0.47) | LMNARAB9ANPC1HTTMEN1 | |
| SCHEMBL23632129 | 0.80 | RORC (0.39) | LMNAHTTGAA | |
| SCHEMBL28619569 | 0.80 | RORC (0.39) | LMNAHTTGAA | |
| SCHEMBL27888280 | 0.80 | CNR2 (0.49) | UTS2RALDH1A1RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118239948-A | Solid forms and methods of making fused tricyclic compounds, including methods of use thereof | 豪夫迈·罗氏有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-117946107-A | Solid forms and methods of making fused tricyclic compounds, including methods of use thereof | 豪夫迈·罗氏有限公司 | 2024-04-30 | — | — | CN | disclosed |