Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 4/20 | 0.66 |
| ▸ | WDR5 | P61964 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RBBP5 | Q15291 | 1/20 | 0.51 |
| ▸ | ASH2L | Q9UBL3 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29204824 | 0.94 | XPO1 (0.61) | XPO1WDR5KDM4ETP53MAPT | |
| SCHEMBL29204842 | 0.90 | XPO1 (0.80) | XPO1KDM4ETP53MAPTGAA | |
| SCHEMBL29204810 | 0.90 | XPO1 (0.70) | XPO1WDR5KDM4EMAPTLMNA | |
| SCHEMBL29204834 | 0.84 | XPO1 (0.63) | XPO1WDR5KDM4ETP53MAPT | |
| SCHEMBL29204835 | 0.84 | XPO1 (0.74) | XPO1TP53MAPTGAALMNA | |
| SCHEMBL29204837 | 0.84 | XPO1 (0.65) | XPO1WDR5TP53MAPTGAA | |
| SCHEMBL29204806 | 0.81 | WDR5 (0.61) | XPO1WDR5KDM4EMAPTLMNA | |
| SCHEMBL29204803 | 0.80 | SRPK1 (0.54) | XPO1WDR5TP53MAPTGAA | |
| SCHEMBL30883146 | 0.79 | XPO1 (0.88) | XPO1KDM4ETP53MAPTLMNA | |
| SCHEMBL29204813 | 0.79 | WDR5 (0.57) | XPO1WDR5KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964578-A | Non-covalent CRM1 inhibitor and preparation method and application thereof | 四川大学 | 2024-05-03 | — | — | CN | disclosed |