Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 5/20 | 0.45 |
| ▸ | MMP2 | P08253 | 3/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 7/20 | 0.43 |
| ▸ | MMP13 | P45452 | 6/20 | 0.43 |
| ▸ | MMP3 | P08254 | 4/20 | 0.42 |
| ▸ | MMP7 | P09237 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KLK7 | P49862 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1656130 | 0.81 | MMP1 (0.62) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL5532810 | 0.81 | MMP1 (0.62) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1656023 | 0.74 | MMP9 (0.75) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL13201347 | 0.71 | MMP9 (0.61) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1656257 | 0.67 | MMP9 (0.68) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL5532812 | 0.66 | MMP1 (0.44) | MMP9MMP1MMP13MMP3MMP7 | |
| SCHEMBL1655811 | 0.66 | MMP9 (0.68) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1655768 | 0.65 | MMP2 (0.66) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL2927547 | 0.65 | MMP9 (0.75) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1656118 | 0.65 | MMP9 (0.72) | MMP9MMP2MMP12MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768979-B1 | OCTAHYDROPYRROLO[2, 3, C]PYRIDINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | MERCK SERONO SA (CH) | 2010-09-29 | — | — | EP | claimed |