Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 7/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2923960 | 0.91 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2DRD2SIGMAR1ADRB1 | |
| SCHEMBL10104322 | 0.91 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2DRD2SIGMAR1ADRB1 | |
| SCHEMBL2927915 | 0.90 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2DRD2SIGMAR1ADRB1 | |
| SCHEMBL2928287 | 0.86 | ADRB1 (0.56) | ALDH1A1SMN1; SMN2SIGMAR1ADRB1CYP1A2 | |
| SCHEMBL2927397 | 0.84 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2DRD2SIGMAR1CYP1A2 | |
| SCHEMBL13080288 | 0.83 | DRD2 (0.62) | ALDH1A1SMN1; SMN2DRD2SIGMAR1HTR1A | |
| SCHEMBL2098119 | 0.83 | ADRB1 (0.53) | ALDH1A1SMN1; SMN2DRD2SIGMAR1ADRB1 | |
| SCHEMBL11748600 | 0.83 | ADRB1 (0.53) | ALDH1A1SMN1; SMN2DRD2SIGMAR1ADRB1 | |
| Ammonia Solution, Strong SCHEMBL11284383 | 0.83 | ALDH1A1 (0.75) | ALDH1A1SMN1; SMN2DRD2SIGMAR1CYP1A2 | |
| SCHEMBL28692744 | 0.83 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2DRD2SIGMAR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41315-E1 | Modulators of dopamine neurotransmission | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB (DE) | 2010-05-04 | — | — | US | disclosed |
| US-6924374-B2 | Central nervous system disorders; psychological disorders | A. CARLSSON RESEARCH AB (SE) | 2005-08-02 | — | — | US | disclosed |
| EP-1419773-A2 | 4-Phenylpiperidine derivatives as modulators of dopamine neurotransmission | A. Carlsson Research AB (SE) | 2004-05-19 | — | — | EP | disclosed |
| US-20030004169-A1 | Modulators of dopamine neurotransmission | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2003-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004169-A1 | Modulators of dopamine neurotransmission | OPRD1, OPRK1, OPRM1 | ALDH1A1 2318/4885SMN1; SMN2 904/4885DRD2 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.