Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2336876 | 0.92 | EPHX2 (0.40) | EPHX2MEN1GAAKMT2AHDAC8 | |
| SCHEMBL2332922 | 0.92 | EPHX2 (0.40) | EPHX2MEN1GAAKMT2AHDAC8 | |
| SCHEMBL2331646 | 0.92 | EPHX2 (0.40) | EPHX2MEN1GAAKMT2AHDAC8 | |
| SCHEMBL28302938 | 0.88 | HDAC3 (0.38) | EPHX2MEN1GAAKMT2AHDAC8 | |
| SCHEMBL11193635 | 0.86 | HDAC8 (0.38) | EPHX2MEN1GAAKMT2AHDAC8 | |
| SCHEMBL26660516 | 0.85 | EPHX2 (0.35) | EPHX2MEN1GAAKMT2AHDAC8 | |
| SCHEMBL23416460 | 0.83 | LTA4H (0.39) | EPHX2MEN1GAAKMT2AHDAC8 | |
| SCHEMBL3176136 | 0.83 | LTA4H (0.39) | EPHX2MEN1GAAKMT2AHDAC8 | |
| SCHEMBL12463782 | 0.83 | GSR (0.46) | MEN1KMT2ATSHRNOS1NOS3 | |
| SCHEMBL22878139 | 0.83 | LTA4H (0.39) | EPHX2MEN1GAAKMT2AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666767-B1 | PHTHALAZINONE DERIVATIVES, METHOD FOR THEIR PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING THEM, AND THEIR USE | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2021-12-01 | — | — | EP | disclosed |
| US-11040952-B2 | Phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2021-06-22 | — | — | US | disclosed |
| EP-3666767-A1 | PYRIDAZINONE COMPOUND, METHOD FOR PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2020-06-17 | — | — | EP | disclosed |
| US-20200181109-A1 | PHTHALAZINONE COMPOUND, METHOD FOR PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2020-06-11 | — | — | US | disclosed |
| EP-1470101-B1 | NEW OPIOID DERIVATIVE | TEIKOKU SEIYAKU KK (JP) | 2010-09-29 | — | — | EP | disclosed |
| US-6838580-B2 | Opioid derivative | TEIKOKU SEIYAKU CO., LTD. (JP) | 2005-01-04 | — | — | US | disclosed |
| US-20030171302-A1 | Opioid derivative | TEIKOKU SEIYAKU CO., LTD. (JP) | 2003-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200181109-A1 | PHTHALAZINONE COMPOUND, METHOD FOR PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | POLRMT, POLN, HCCS | EPHX2 3930/4885MEN1 1457/4885GAA 1664/4885 |
| US-20030171302-A1 | Opioid derivative | OPRD1, OPRM1, OPRK1 | EPHX2 4090/4885MEN1 4251/4885GAA 4863/4885 |
| US-11040952-B2 | Phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and use thereof | POLRMT, POLN, HCCS | EPHX2 3930/4885MEN1 1457/4885GAA 1664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.