Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.37 |
| ▸ | S100A10 | P60903 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19914058 | 0.85 | ALDH1A1 (0.86) | ALDH1A1CYP1A2CYP1A1CYP1B1CYP2A6 | |
| SCHEMBL6848984 | 0.83 | ALDH1A1 (0.47) | ALDH1A1CYP2A6ANXA2S100A10RAB9A | |
| SCHEMBL26861180 | 0.82 | ANXA2 (0.40) | ALDH1A1CYP1A2CYP1A1CYP1B1MEN1 | |
| SCHEMBL27461205 | 0.82 | ALDH1A1 (0.38) | ALDH1A1CYP1A2MEN1KMT2AMAPT | |
| SCHEMBL17521461 | 0.82 | ALDH1A1 (0.47) | ALDH1A1CYP2A6MAPTNPC1NOTUM | |
| SCHEMBL28439021 | 0.80 | NOTUM (0.42) | ALDH1A1CYP1A2MEN1KMT2AMAPT | |
| SCHEMBL711416 | 0.79 | ALDH1A1 (0.56) | ALDH1A1CYP1A2CYP1A1CYP1B1CYP2A6 | |
| SCHEMBL29951214 | 0.79 | ALDH1A1 (0.56) | ALDH1A1CYP1A2CYP1A1CYP1B1CYP2A6 | |
| SCHEMBL21770156 | 0.79 | ALDH1A1 (0.57) | ALDH1A1CYP2A6MEN1KMT2AMAPT | |
| SCHEMBL15240600 | 0.79 | POLB (0.50) | ALDH1A1MEN1KMT2ANOTUMANXA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140336160-A1 | NOVEL GLUCOCORTICOLD RECEPTOR AGONISTS | PFIZER (US) | 2014-11-13 | — | — | US | disclosed |
| US-20140336160-A1 | NOVEL GLUCOCORTICOLD RECEPTOR AGONISTS | PFIZER (US) | 2014-11-13 | — | — | US | disclosed |
| US-20140336160-A1 | NOVEL GLUCOCORTICOLD RECEPTOR AGONISTS | PFIZER (US) | 2014-11-13 | — | — | US | disclosed |
| US-8822439-B2 | Glucocorticoid receptor agonists | PFIZER INC. (US) | 2014-09-02 | — | — | US | disclosed |
| US-8822439-B2 | Glucocorticoid receptor agonists | PFIZER INC. (US) | 2014-09-02 | — | — | US | disclosed |
| US-8822439-B2 | Glucocorticoid receptor agonists | PFIZER INC. (US) | 2014-09-02 | — | — | US | disclosed |
| EP-2225256-B1 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | PFIZER LTD (GB) | 2013-01-09 | — | — | EP | disclosed |
| EP-2225256-B1 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | PFIZER LTD (GB) | 2013-01-09 | — | — | EP | disclosed |
| EP-2225256-A2 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | Pfizer Limited (GB) | 2010-09-08 | — | — | EP | disclosed |
| US-20090227548-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2009-09-10 | — | — | US | disclosed |
| US-20090227548-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2009-09-10 | — | — | US | disclosed |
| US-20090227548-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2009-09-10 | — | — | US | disclosed |
| WO-2009069032-A2 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | PFIZER LIMITED (GB) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009069032-A2 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | PFIZER LIMITED (GB) | 2009-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227548-A1 | Novel Glucocorticoid Receptor Agonists | NR3C1, NR3C2, MC2R | ALDH1A1 2013/4885CYP1A2 461/4885CYP1A1 428/4885 |
| US-20140336160-A1 | NOVEL GLUCOCORTICOLD RECEPTOR AGONISTS | NR3C1, TSLP, MRGPRX2 | ALDH1A1 2281/4885CYP1A2 540/4885CYP1A1 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.