SCHEMBL2925499

SCHEMBL2925499

O=C(O)c1ccc(Cl)c2c1[nH]c1c3ccc(C(F)(F)F)cc3oc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNMA1 Q12791 1/20 1.00
ADRA2A P08913 1/20 0.40
CLCN2 P51788 1/20 0.40
ALDH1A1 P00352 3/20 0.39
HPGD P15428 3/20 0.39
KDM4E B2RXH2 2/20 0.39
HSD17B10 Q99714 2/20 0.39
PIM1 P11309 2/20 0.39
PIM2 Q9P1W9 2/20 0.39
MPL P40238 2/20 0.39
MEN1 O00255 1/20 0.39
CYP1A2 P05177 1/20 0.39
ALOX12 P18054 1/20 0.39
KMT2A Q03164 1/20 0.39
MRGPRX4 Q96LA9 1/20 0.37
SORT1 Q99523 1/20 0.36
USP2 O75604 1/20 0.36
CYP2C19 P33261 1/20 0.36
PBRM1 Q86U86 1/20 0.36
ACLY P53396 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18022312 0.83 KCNMA1 (0.71) KCNMA1ADRA2ACLCN2KDM4EPIM1
SCHEMBL2925491 0.81 KCNMA1 (0.68) KCNMA1ALDH1A1HPGDKDM4EHSD17B10
SCHEMBL2933540 0.81 KCNMA1 (0.67) KCNMA1ALDH1A1HPGDKDM4EHSD17B10
SCHEMBL2925140 0.76 KCNMA1 (0.61) KCNMA1HSD17B10PIM1PIM2MEN1
SCHEMBL2931881 0.73 KCNMA1 (0.57) KCNMA1PIM1PIM2CSNK2A2CSNK2B
SCHEMBL2932784 0.72 KCNMA1 (0.57) KCNMA1ALDH1A1PIM1PIM2PBRM1
SCHEMBL17536384 0.71 KCNMA1 (0.55) KCNMA1ALDH1A1HPGDKDM4EHSD17B10
SCHEMBL2931043 0.68 KCNMA1 (0.52) KCNMA1ALDH1A1HPGDKDM4EHSD17B10
SCHEMBL2931271 0.68 KCNMA1 (0.50) KCNMA1KDM4EMEN1KMT2A
SCHEMBL78221 0.67 MRGPRX4 (0.61) KCNMA1ALDH1A1HPGDKDM4EHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180021303-A1 BKCA CHANNEL ACTIVATOR FOR TREATING MUSCULAR DISORDER CANBEX THERAPEUTICS LTD (GB) 2018-01-25 US claimed
EP-3256122-A1 BKCA CHANNEL ACTIVATOR FOR TREATING MUSCULAR DISORDER Canbex Therapeutics Limited (GB) 2017-12-20 EP claimed
US-20160235710-A1 COMPOSITION FOR TREATING OR PREVENTING ERECTILE DYSFUNCTION COMPRISING LDD175 AS ACTIVE INGREDIENT SNU R&D FOUNDATION (KR) 2016-08-18 US claimed
WO-2016128772-A1 BKCA CHANNEL ACTIVATOR FOR TREATING MUSCULAR DISORDER CANBEX THERAPEUTICS LIMITED (GB) 2016-08-18 WO claimed
US-11517556-B2 Composition for BKCa channel activation GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2022-12-06 US disclosed
WO-2022075780-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OVERACTIVE BLADDER 광주과학기술원 2022-04-14 WO disclosed
US-20200069640-A1 COMPOSITION FOR BKCA CHANNEL ACTIVATION GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2020-03-05 US disclosed
US-20190083456-A1 COMPOSITION FOR BKCA CHANNEL ACTIVATION GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2019-03-21 US disclosed
US-20180021303-A1 BKCA CHANNEL ACTIVATOR FOR TREATING MUSCULAR DISORDER CANBEX THERAPEUTICS LTD (GB) 2018-01-25 US disclosed
EP-3256122-A1 BKCA CHANNEL ACTIVATOR FOR TREATING MUSCULAR DISORDER Canbex Therapeutics Limited (GB) 2017-12-20 EP disclosed
WO-2017160128-A1 COMPOSITION FOR ACTIVATION OF BKCA CHANNELS 광주과학기술원 2017-09-21 WO disclosed
US-20160235710-A1 COMPOSITION FOR TREATING OR PREVENTING ERECTILE DYSFUNCTION COMPRISING LDD175 AS ACTIVE INGREDIENT SNU R&D FOUNDATION (KR) 2016-08-18 US disclosed
WO-2016128772-A1 BKCA CHANNEL ACTIVATOR FOR TREATING MUSCULAR DISORDER CANBEX THERAPEUTICS LIMITED (GB) 2016-08-18 WO disclosed
US-20160061816-A1 SCREENING METHOD FOR ION CHANNEL MODULATORS USING MUTATED BKCA CHANNEL GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2016-03-03 US disclosed
US-7812177-B2 Potassium channel opener having benzofuroindole skeleton ANYGEN CO., LTD. (KR) 2010-10-12 US disclosed
EP-1861092-B1 POTASSIUM CHANNEL OPENER HAVING BENZOFUROINDOLE SKELETON ANYGEN CO LTD (KR) 2010-09-15 EP disclosed
EP-1861092-A4 POTASSIUM CHANNEL OPENER HAVING BENZOFUROINDOLE SKELETON ANYGEN CO LTD (KR) 2009-04-15 EP disclosed
US-20080194837-A1 Potassium Channel Opener Having Benzofuroindole Skeleton ANYGEN CO., LTD. (KR) 2008-08-14 US disclosed
EP-1861092-A1 POTASSIUM CHANNEL OPENER HAVING BENZOFUROINDOLE SKELETON Anygen Co., Ltd. (KR) 2007-12-05 EP disclosed
WO-2006096030-A1 POTASSIUM CHANNEL OPENER HAVING BENZOFUROINDOLE SKELETON ANYGEN CO., LTD. (KR) 2006-09-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200069640-A1 COMPOSITION FOR BKCA CHANNEL ACTIVATION KCNAB1, KCNN3, KCNC1 KCNMA1 8/4885ADRA2A 534/4885CLCN2 150/4885
US-20180021303-A1 BKCA CHANNEL ACTIVATOR FOR TREATING MUSCULAR DISORDER KCNMA1, KCNMB1, KCNA1 KCNMA1 1/4885ADRA2A 777/4885CLCN2 261/4885
US-11517556-B2 Composition for BKCa channel activation KCNAB1, KCNN3, KCNC1 KCNMA1 8/4885ADRA2A 534/4885CLCN2 150/4885
US-20160235710-A1 COMPOSITION FOR TREATING OR PREVENTING ERECTILE DYSFUNCTION COMPRISING LDD175 AS ACTIVE INGREDIENT PDE5A, PDE3A, PDE2A KCNMA1 56/4885ADRA2A 227/4885CLCN2 1138/4885
US-20080194837-A1 Potassium Channel Opener Having Benzofuroindole Skeleton KCNJ2, KCNN3, KCNH2 KCNMA1 41/4885ADRA2A 1109/4885CLCN2 85/4885
US-20190083456-A1 COMPOSITION FOR BKCA CHANNEL ACTIVATION KCNAB1, KCNN3, KCNC1 KCNMA1 8/4885ADRA2A 534/4885CLCN2 150/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.