Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4180955 | 0.91 | KDM4E (0.31) | KDM4EUSP2ALDH1A1LMNAMMP9 | |
| SCHEMBL13522993 | 0.86 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1LMNACNR1CNR2 | |
| SCHEMBL2929857 | 0.85 | POLB (0.31) | KDM4EUSP2ALDH1A1LMNAMMP9 | |
| SCHEMBL2932350 | 0.85 | HTT (0.41) | SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL2930475 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1LMNATSHRCNR1 | |
| SCHEMBL2923471 | 0.81 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1CNR1CNR2 | |
| SCHEMBL27603443 | 0.78 | SMN1; SMN2 (0.40) | SMN1; SMN2CNR1CNR2 | |
| SCHEMBL5409719 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1CNR1CNR2 | |
| SCHEMBL3141869 | 0.76 | HTT (0.33) | SMN1; SMN2KDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL8920720 | 0.71 | MAPT (0.41) | SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1891192-B | Composition for dyeing keratin fibers, comprising a diamino-n,n-dihydropyrazolone compound, a coupler, and a polyol | OREAL | 2011-11-16 | — | — | CN | disclosed |
| EP-1733713-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone dervative, a coupling agent and a selected surface-active agent | OREAL (FR) | 2010-06-02 | — | — | EP | disclosed |
| EP-1733714-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone derivative, a coupling agent and a polyol | OREAL (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1733716-B1 | Composition for dyeing keratin fibres comprising a diamino-N,N-dihydro-pyrazolone derivative, a coupling agent and an associative polyurethane polymer | OREAL (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1728500-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolon derivative and a cationic oxidation dye | OREAL (FR) | 2010-01-27 | — | — | EP | disclosed |
| EP-1733715-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone derivative, a coupling agent and a heterocyclic direct dye | OREAL (FR) | 2010-01-27 | — | — | EP | disclosed |
| EP-1728499-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone derivative and a 2,3-diaminopyridine coupler | OREAL (FR) | 2010-01-06 | — | — | EP | disclosed |
| US-7642360-B2 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | L'OREAL S.A. (FR) | 2010-01-05 | — | — | US | disclosed |
| US-7582121-B2 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one heterocyclic direct dye | L'OREAL S.A. (FR) | 2009-09-01 | — | — | US | disclosed |
| US-7582121-B2 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one heterocyclic direct dye | L'OREAL S.A. (FR) | 2009-09-01 | — | — | US | disclosed |
| EP-1733713-A1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone dervative, a coupling agent and a selected surface-active agent | L'OREAL (FR) | 2006-12-20 | — | — | EP | disclosed |
| EP-1733715-A1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone derivative, a coupling agent and a heterocyclic direct dye | L'OREAL (FR) | 2006-12-20 | — | — | EP | disclosed |
| EP-1733716-A1 | Composition for dyeing keratin fibres comprising a diamino-N,N-dihydro-pyrazolone derivative, a coupling agent and an associative polyurethane polymer | L'OREAL (FR) | 2006-12-20 | — | — | EP | disclosed |
| US-20060277691-A1 | Composition for dyeing keratin fibers, comprising a diamino-N,N-dihydropyrazolone compound, a coupler, and a polyol | L'OREAL S.A. (FR) | 2006-12-14 | — | — | US | disclosed |
| US-20060277693-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler and at least one associative polyurethane polymer | L'OREAL S.A. (FR) | 2006-12-14 | — | — | US | disclosed |
| US-20060277692-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one surfactant | L'OREAL S.A. (FR) | 2006-12-14 | — | — | US | disclosed |
| EP-1728499-A1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone derivative and a 2,3-diaminopyridine coupler | L'OREAL (FR) | 2006-12-06 | — | — | EP | disclosed |
| EP-1728500-A1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolon derivative and a cationic oxidation dye | L'OREAL (FR) | 2006-12-06 | — | — | EP | disclosed |
| US-20050166335-A1 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | L'OREAL S.A. (FR) | 2005-08-04 | — | — | US | disclosed |
| EP-1550656-A1 | 4-5-diamino-n,n-dihydro-pyrazol-3-one derivatives for use in composition for dyeing keratin fibres | L'OREAL (FR) | 2005-07-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060277691-A1 | Composition for dyeing keratin fibers, comprising a diamino-N,N-dihydropyrazolone compound, a coupler, and a polyol | KRT18, C9, NDUFA10 | SMN1; SMN2 4349/4885KDM4E 1887/4885USP2 3659/4885 |
| US-20060277692-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one surfactant | KRT18, DSP, DSG1 | SMN1; SMN2 4694/4885KDM4E 2956/4885USP2 3830/4885 |
| US-20050166335-A1 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | KRT18, DAO, AOC1 | SMN1; SMN2 4116/4885KDM4E 1547/4885USP2 4690/4885 |
| US-20060277693-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler and at least one associative polyurethane polymer | KRT18, PRKDC, DSP | SMN1; SMN2 4506/4885KDM4E 1001/4885USP2 2784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.