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Sugi Predict / Targets / NDUFA10

NDUFA10

NADH-ubiquinone oxidoreductase 42 kDa subunit · O95299 · NDUFA10 on Sugi Atlas →

3,154 patent compounds predicted against NDUFA10, 1,934 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Auraptene Auraptene (SCHEMBL2535029) 1.00 5/20
Auraptene Auraptene (SCHEMBL2535034) 1.00 5/20
SCHEMBL8491443 SCHEMBL8491443 0.56 4/20
SCHEMBL8489900 SCHEMBL8489900 0.52 4/20
SCHEMBL8489907 SCHEMBL8489907 0.52 4/20
SCHEMBL8492838 SCHEMBL8492838 0.52 4/20
SCHEMBL8492845 SCHEMBL8492845 0.52 4/20
SCHEMBL8489902 SCHEMBL8489902 0.51 4/20
SCHEMBL8489908 SCHEMBL8489908 0.51 4/20
SCHEMBL8491154 SCHEMBL8491154 0.51 4/20
SCHEMBL8491160 SCHEMBL8491160 0.51 4/20
SCHEMBL8491619 SCHEMBL8491619 0.50 4/20
SCHEMBL8491624 SCHEMBL8491624 0.50 4/20
SCHEMBL8491634 SCHEMBL8491634 0.50 4/20
7-Prenyloxycoumarin 7-Prenyloxycoumarin (SCHEMBL4898255) 0.79 3/20
SCHEMBL712741 SCHEMBL712741 0.57 3/20
Geiparvarin Geiparvarin (SCHEMBL2532495) 0.56 3/20
SCHEMBL6267768 SCHEMBL6267768 0.55 3/20
SCHEMBL1095981 SCHEMBL1095981 0.55 3/20
SCHEMBL4293165 SCHEMBL4293165 0.55 3/20

Clinical trials — most relevant to NDUFA10 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
Effect of Montelukast Versus Co Enzyme in Sepsis PHASE2/PHASE3COMPLETED
A Study of Efficacy, Safety and Tolerability of Idebenone in the Treatment of Friedreich's Ataxia (FRDA) Patients PHASE3COMPLETED
Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease PHASE3COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease PHASE2COMPLETED
Ubiquinol (Reduced COQ10) for Patients With Sepsis PHASE2COMPLETED
Efficacy and Safety Study of Bilateral IVT Injection of GS010 at Two Dose Levels in LHON Patients PHASE2RECRUITING
Parkinson's Disease Treatment With Coenzyme Q10 PHASE2COMPLETED
Effects of Coenzyme Q10 on Charcot-Marie-Tooth Disease PHASE1/PHASE2COMPLETED
Clinical Trial of High Dose CoQ10 in ALS PHASE2COMPLETED
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy PHASE2ACTIVE_NOT_RECRUITING
Study About Safety and Efficacy of Coenzyme Q10 in Progressive Supranuclear Palsy PHASE2COMPLETED
An Open-label Pilot Study of Coenzyme Q10 in Steroid-Treated Duchenne Muscular Dystrophy PHASE2COMPLETED
Bioavailability of Ubiquinone and Ubiquinol in Older Adults PHASE1COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
The Natural History of Mitochondrial Diseases nanRECRUITING
Assessment of Follicular Fluid Level of Coenzyme Q10 in Women Undergoing ICSI nanUNKNOWN
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Q10 Ubiquinol in Autism Spectrum Disorder and in Phelan-McDermid Syndrome. nanUNKNOWN
Pharmacokinetic Study on Three Formulations of Coenzyme Q10 With Different Carriers nanUNKNOWN
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Coenzyme Q10 Plus NADH Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis nanCOMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
Fasting Tolerance in MCADD-infants nanUNKNOWN
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability. nanUNKNOWN
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a NDUFA10 binder may also engage these)

ProteinNameSimilarity
P0CB90 — 1.000 P0CB90 →
Q99LC3 — 1.000 Q99LC3 →
Q0MQB6 — 1.000 Q0MQB6 →
Q0MQB7 — 1.000 Q0MQB7 →
P0CB89 — 1.000 P0CB89 →
Q561S0 — 1.000 Q561S0 →
P91929 — 0.987 P91929 →
P34942 — 0.986 P34942 →
Q5R981 — 0.983 Q5R981 →
Q8N1G2 — 0.980 Q8N1G2 →
P37101 — 0.978 P37101 →
Q9VPB1 — 0.978 Q9VPB1 →
Q8IYB8 — 0.978 Q8IYB8 →
Q9WVK4 — 0.978 Q9WVK4 →
P31717 — 0.978 P31717 →
Q9DBC3 — 0.977 Q9DBC3 →
Q9ER88 — 0.977 Q9ER88 →
NMT2 Glycylpeptide N-tetradecanoyltransferase 2 0.977 landscape →
Q5RAP2 — 0.977 Q5RAP2 →
Q5E9R3 — 0.977 Q5E9R3 →
P10759 — 0.977 P10759 →
Q91YL3 — 0.977 Q91YL3 →
Q5I598 — 0.976 Q5I598 →
Q5BK63 — 0.976 Q5BK63 →
A7S641 — 0.976 A7S641 →
P58347 — 0.976 P58347 →
C0NLX2 — 0.976 C0NLX2 →
Q922E4 — 0.976 Q922E4 →
AMPD1 AMP deaminase 1 0.976 landscape →
COASY Bifunctional coenzyme A synthase 0.976 landscape →