Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2923501 | 0.80 | MEN1 (0.37) | HTTCYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL2929425 | 0.80 | MAPT (0.32) | L3MBTL1MAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL14401659 | 0.80 | HTT (0.37) | HTTCYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL2929857 | 0.78 | POLB (0.31) | HTTALDH1A1LMNAKDM4EUSP2 | |
| SCHEMBL27622210 | 0.77 | MAPT (0.39) | HTTCYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL2926366 | 0.76 | SMN1; SMN2 (0.34) | ALDH1A1LMNAKDM4EUSP2MMP9 | |
| SCHEMBL4180955 | 0.76 | KDM4E (0.31) | ALDH1A1LMNAKDM4EUSP2MMP9 | |
| SCHEMBL2932350 | 0.72 | HTT (0.41) | HTTCYP1A2CYP2C19CYP2C9MAPT | |
| SCHEMBL13356460 | 0.65 | MEN1 (0.39) | HTTCYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL25170227 | 0.65 | CA12 (0.36) | HTTCYP1A2L3MBTL1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1891192-B | Composition for dyeing keratin fibers, comprising a diamino-n,n-dihydropyrazolone compound, a coupler, and a polyol | OREAL | 2011-11-16 | — | — | CN | disclosed |
| US-7642360-B2 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | L'OREAL S.A. (FR) | 2010-01-05 | — | — | US | disclosed |
| US-7582121-B2 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one heterocyclic direct dye | L'OREAL S.A. (FR) | 2009-09-01 | — | — | US | disclosed |
| US-7488355-B2 | Composition for dyeing keratin fibers, comprising a diamino-N,N-dihydropyrazolone compound, a coupler, and a polyol | L'OREAL S.A. (FR) | 2009-02-10 | — | — | US | disclosed |
| US-7488356-B2 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one surfactant | L'OREAL S.A. (FR) | 2009-02-10 | — | — | US | disclosed |
| US-7485156-B2 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler and at least one associative polyurethane polymer | L'OREAL S.A. (FR) | 2009-02-03 | — | — | US | disclosed |
| US-20080071092-A1 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | L'OREAL S.A. | 2008-03-20 | — | — | US | disclosed |
| US-7285137-B2 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | L'OREAL, S.A. (FR) | 2007-10-23 | — | — | US | disclosed |
| US-20070006398-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one heterocyclic direct dye | L'OREAL S.A. (FR) | 2007-01-11 | — | — | US | disclosed |
| CN-1891192-A | Composition for dyeing keratin fibers, comprising a diamino-n,n-dihydropyrazolone compound, a coupler, and a polyol | OREAL (FR) | 2007-01-10 | — | — | CN | disclosed |
| US-20060277691-A1 | Composition for dyeing keratin fibers, comprising a diamino-N,N-dihydropyrazolone compound, a coupler, and a polyol | L'OREAL S.A. (FR) | 2006-12-14 | — | — | US | disclosed |
| US-20060277693-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler and at least one associative polyurethane polymer | L'OREAL S.A. (FR) | 2006-12-14 | — | — | US | disclosed |
| US-20060277692-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one surfactant | L'OREAL S.A. (FR) | 2006-12-14 | — | — | US | disclosed |
| US-20050166335-A1 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | L'OREAL S.A. (FR) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060277691-A1 | Composition for dyeing keratin fibers, comprising a diamino-N,N-dihydropyrazolone compound, a coupler, and a polyol | KRT18, C9, NDUFA10 | HTT 2572/4885CYP1A2 2747/4885CYP2C19 2230/4885 |
| US-20060277692-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one surfactant | KRT18, DSP, DSG1 | HTT 3330/4885CYP1A2 3432/4885CYP2C19 3723/4885 |
| US-20080071092-A1 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | KRT18, DAO, AOC1 | HTT 2367/4885CYP1A2 1812/4885CYP2C19 1905/4885 |
| US-20050166335-A1 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | KRT18, DAO, AOC1 | HTT 2367/4885CYP1A2 1812/4885CYP2C19 1905/4885 |
| US-20060277693-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler and at least one associative polyurethane polymer | KRT18, PRKDC, DSP | HTT 2398/4885CYP1A2 3184/4885CYP2C19 2520/4885 |
| US-20070006398-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one heterocyclic direct dye | KRT18, DSP, DSG1 | HTT 2210/4885CYP1A2 2601/4885CYP2C19 2699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.