Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 3/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
| ▸ | IL1B | P01584 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31307995 | 0.82 | HCRTR2 (0.35) | HCRTR2HCRTR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29277456 | 0.77 | SLC6A9 (0.39) | HCRTR2HCRTR1ACACBALOX5APFEN1 | |
| SCHEMBL29277434 | 0.76 | LIPE (0.47) | ACACB | |
| SCHEMBL29277464 | 0.76 | LOXL2 (0.31) | — | |
| SCHEMBL31532572 | 0.74 | SLC6A4 (0.38) | HCRTR2HCRTR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28358308 | 0.73 | HCRTR1 (0.53) | HCRTR2HCRTR1 | |
| SCHEMBL29277466 | 0.72 | MALT1 (0.43) | ACACBALOX5APFEN1 | |
| SCHEMBL29277439 | 0.72 | ACACB (0.39) | HCRTR2HCRTR1ACACBALOX5APFEN1 | |
| SCHEMBL21607008 | 0.72 | HRH1 (0.41) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28613739 | 0.71 | HCRTR1 (0.38) | HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| CN-117295726-A | Heterocyclic compounds | 豪夫迈·罗氏有限公司 | 2023-12-26 | — | — | CN | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| CN-117295726-A | Heterocyclic compounds | 豪夫迈·罗氏有限公司 | 2023-12-26 | — | — | CN | disclosed |