Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | TPMT | P51580 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL160742 | 0.84 | MAPT (0.42) | CA1CA2HTTRAB9ALMNA | |
| SCHEMBL299808 | 0.82 | CA1 (0.52) | CA1CA2CA12CA7CA9 | |
| SCHEMBL1303876 | 0.82 | PARP10 (0.52) | CA1CA2HTTTSHRMAPK1 | |
| SCHEMBL743687 | 0.79 | HPGD (0.47) | CA1CA2KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL745459 | 0.79 | PLK1 (0.55) | CA1CA2HTTTSHRLMNA | |
| SCHEMBL8181944 | 0.77 | CA12 (0.51) | CA1CA2CA12CA7CA9 | |
| SCHEMBL2747933 | 0.77 | NPC1 (0.53) | TSHRTP53RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17749717 | 0.75 | KMT2A (0.42) | CA1CA2CA12CA9TP53 | |
| SCHEMBL7114596 | 0.74 | PRSS1 (0.52) | LMNA | |
| SCHEMBL17749770 | 0.74 | HPGD (0.55) | HTTKDM4ELMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10556914-B2 | Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use | ABBVIE INC. (US) | 2020-02-11 | — | — | US | claimed |
| EP-3350187-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | AbbVie Inc. (US) | 2018-07-25 | — | — | EP | claimed |
| WO-2017046117-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | ABBVIE INC. (US) | 2017-03-23 | — | — | WO | claimed |
| US-20170073353-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-03-16 | — | — | US | claimed |
| CN-103214432-A | 5-methyl-1,2,3-thiadiazole based alpha-(substituted)oxyamide derivatives and preparation methods and application thereof | UNIV NANKAI | 2013-07-24 | — | — | CN | claimed |
| CN-103214475-A | Alpha-(substituted)oxyamide derivatives containing 4-methyl-1,2,3-thiadiazole and preparation methods and application thereof | UNIV NANKAI | 2013-07-24 | — | — | CN | claimed |
| EP-1789398-B1 | 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF B-SECRETASE (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-29 | — | — | EP | claimed |
| EP-1789398-A1 | 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF B-SECRETASE (BACE) | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-30 | — | — | EP | claimed |
| US-20060178383-A1 | Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-08-10 | — | — | US | claimed |
| WO-2006024932-A1 | 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF B-SECRETASE (BACE) | JANSSEN PHARMACEUTICA, N.V. (US) | 2006-03-09 | — | — | WO | claimed |
| CN-118176419-A | Reagent for measuring concentration of biological component, measuring method, and sensor | 泰尔茂株式会社 | 2024-06-11 | — | — | CN | disclosed |
| CN-111788472-B | Method, reagent and chip for determining concentration of analyte in biological sample | 泰尔茂株式会社 | 2023-12-15 | — | — | CN | disclosed |
| US-11815448-B2 | Method, reagent, and chip for measuring analyte concentration in specimen | TERUMO KABUSHIKI KAISHA (JP) | 2023-11-14 | — | — | US | disclosed |
| US-11739083-B2 | Disposable sensor chip with reagent including 2-substituted benzothiazolyl-3-substituted phenyl-5-substituted sulfonated phenyl-2H-tetrazolium salt | TERUMO KABUSHIKI KAISHA (JP) | 2023-08-29 | — | — | US | disclosed |
| WO-2023112442-A1 | BIOLOGICAL COMPONENT CONCENTRATION MEASUREMENT REAGENT, MEASUREMENT METHOD, AND SENSOR | テルモ株式会社 | 2023-06-22 | — | — | WO | disclosed |
| EP-0468649-A1 | Anionic compounds | ZENECA LIMITED (GB) | 1992-01-29 | — | — | EP | disclosed |
| EP-0460550-A1 | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1991-12-11 | — | — | EP | disclosed |
| US-4853328-A | Reagent for assaying hydrogen peroxide and method of quantitative assay for hydrogen peroxide | FUJI PHOTO FILM CO., LTD. (JP) | 1989-08-01 | — | — | US | disclosed |
| EP-0060518-B2 | REAGENT FOR ASSAYING HYDROGEN PEROXIDE AND METHOD OF QUANTITATIVE ASSAY FOR HYDROGEN PEROXIDE | FUJI PHOTO FILM CO., LTD. (JP) | 1988-09-21 | — | — | EP | disclosed |
| EP-0060518-B1 | REAGENT FOR ASSAYING HYDROGEN PEROXIDE AND METHOD OF QUANTITATIVE ASSAY FOR HYDROGEN PEROXIDE | FUJI PHOTO FILM CO., LTD. (JP) | 1985-07-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10556914-B2 | Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use | GABRB1, GABBR1, GABBR2 | CA1 2171/4885CA2 1282/4885CA12 3730/4885 |
| US-20060178383-A1 | Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) | BACE2, BACE1, APP | CA1 1564/4885CA2 1483/4885CA12 3928/4885 |
| US-11815448-B2 | Method, reagent, and chip for measuring analyte concentration in specimen | STUB1, MPO, ALDH1A2 | CA1 2095/4885CA2 3576/4885CA12 260/4885 |
| US-11739083-B2 | Disposable sensor chip with reagent including 2-substituted benzothiazolyl-3-substituted phenyl-5-substituted sulfonated phenyl-2H-tetrazolium salt | STUB1, BTK, TST | CA1 1444/4885CA2 822/4885CA12 1177/4885 |
| US-20170073353-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | GABRB1, GABBR1, GABBR2 | CA1 2171/4885CA2 1282/4885CA12 3730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.