Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20598025 | 0.83 | PTGS2 (0.40) | PTGS2CES2ALOX5 | |
| SCHEMBL23071074 | 0.77 | TYR (0.43) | PTGS2CES2THRBTP53MAPT | |
| SCHEMBL2229760 | 0.77 | TYR (0.43) | PTGS2CES2THRBTP53MAPT | |
| SCHEMBL845559 | 0.77 | HTT (0.46) | PTGS2ALOX5TP53MAPTHSD17B10 | |
| SCHEMBL17171753 | 0.77 | S1PR2 (0.32) | CES2THRBTP53MAPTHSD17B10 | |
| SCHEMBL17171740 | 0.77 | S1PR2 (0.32) | CES2THRBTP53MAPTHSD17B10 | |
| SCHEMBL30606253 | 0.75 | S1PR2 (0.33) | S1PR2S1PR1S1PR3LPAR2TYR | |
| SCHEMBL20313357 | 0.74 | TYR (0.42) | CES2THRBTP53MAPTHSD17B10 | |
| SCHEMBL10000645 | 0.74 | TYR (0.42) | CES2THRBTP53MAPTHSD17B10 | |
| SCHEMBL6057474 | 0.72 | SHBG (0.40) | PTGS2CES2THRBTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10759780-B2 | Hindered amines | 3V SIGMA S.P.A. (IT) | 2020-09-01 | — | — | US | disclosed |
| US-20200239629-A1 | HINDERED POLYMERIC AMINES | 3V SIGMA S.P.A. (IT) | 2020-07-30 | — | — | US | disclosed |
| EP-3424977-B1 | HINDERED POLYMERIC AMINES | 3V SIGMA SPA (IT) | 2020-03-18 | — | — | EP | disclosed |
| EP-3428156-B1 | HINDERED AMINES | 3V SIGMA SPA (IT) | 2020-02-12 | — | — | EP | disclosed |
| US-20190016702-A1 | HINDERED AMINES | 3V SIGMA S.P.A. (IT) | 2019-01-17 | — | — | US | disclosed |
| EP-3428156-A1 | HINDERED AMINES | 3V SIGMA S.p.A (IT) | 2019-01-16 | — | — | EP | disclosed |
| EP-3424977-A1 | HINDERED POLYMERIC AMINES | 3V SIGMA S.p.A (IT) | 2019-01-09 | — | — | EP | disclosed |
| US-20190002631-A1 | HINDERED POLYMERIC AMINES | 3V SIGMA S.P.A. (IT) | 2019-01-03 | — | — | US | disclosed |
| US-9725578-B2 | Sterically hindered polymeric amines and their use as polymer stabilizers | 3V SIGMA S.P.A. (IT) | 2017-08-08 | — | — | US | disclosed |
| EP-2632914-B1 | NEW STERICALLY HINDERED POLYMERIC AMINES AND THEIR USE AS POLYMER STABILIZERS | 3V SIGMA SPA (IT) | 2015-12-16 | — | — | EP | disclosed |
| EP-2366732-B1 | Mixtures of sterically hindered amines for polymer stabilisation | 3V SIGMA SPA (IT) | 2013-06-26 | — | — | EP | disclosed |
| US-8404765-B2 | Sterically hindered amines and use thereof as polymer stabilizers | 3V SIGMA S.P.A. (IT) | 2013-03-26 | — | — | US | disclosed |
| WO-2012153260-A1 | MIXTURE OF STERICALLY HINDERED AMINES FOR POLYMER STABILIZATION | 3V SIGMA S.P.A. (IT) | 2012-11-15 | — | — | WO | disclosed |
| EP-2216364-B9 | Sterically hindered amines and use thereof as polymer stabilizers | 3V SIGMA SPA (IT) | 2012-08-15 | — | — | EP | disclosed |
| WO-2012055965-A1 | NEW STERICALLY HINDERED POLYMERIC AMINES AND THEIR USE AS POLYMER STABILIZERS | 3V SIGMA S.P.A. (IT) | 2012-05-03 | — | — | WO | disclosed |
| EP-2216364-B1 | Sterically hindered amines and use thereof as polymer stabilizers | 3V SIGMA SPA (IT) | 2012-03-14 | — | — | EP | disclosed |
| EP-2366732-A2 | Mixtures of sterically hindered amines for polymer stabilisation | 3V SIGMA S.p.A (IT) | 2011-09-21 | — | — | EP | disclosed |
| US-20110224336-A1 | MIXTURES OF STERICALLY HINDERED AMINES FOR POLYMER STABILIZATION | 3V SIGMA S.P.A. (IT) | 2011-09-15 | — | — | US | disclosed |
| US-20100204371-A1 | STERICALLY HINDERED AMINES AND USE THEREOF AS POLYMER STABILIZERS | 3V SIGMA S.P.A. (IT) | 2010-08-12 | — | — | US | disclosed |
| EP-2216364-A1 | Sterically hindered amines and use thereof as polymer stabilizers | 3V SIGMA S.p.A (IT) | 2010-08-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200239629-A1 | HINDERED POLYMERIC AMINES | PARG, PARN, PUF60 | PTGS2 2722/4885CES2 202/4885ALOX5 1740/4885 |
| US-20100204371-A1 | STERICALLY HINDERED AMINES AND USE THEREOF AS POLYMER STABILIZERS | CBR3, SIGMAR1, NPSR1 | PTGS2 2329/4885CES2 3558/4885ALOX5 911/4885 |
| US-20190016702-A1 | HINDERED AMINES | PARG, TAAR5, PARN | PTGS2 2634/4885CES2 57/4885ALOX5 519/4885 |
| US-10759780-B2 | Hindered amines | PARG, TAAR5, PARN | PTGS2 2634/4885CES2 57/4885ALOX5 519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.