Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 4/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930809 | 0.92 | LMNA (0.40) | ADORA3ADORA2AADORA1 | |
| SCHEMBL3049811 | 0.92 | MEN1 (0.42) | ADORA2ALPAR2 | |
| SCHEMBL2930506 | 0.90 | GPR6 (0.38) | GPR6 | |
| SCHEMBL2929411 | 0.89 | ADORA2A (0.41) | ADORA3ADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL2924971 | 0.89 | CCR3 (0.40) | SMN1; SMN2LPAR2HCAR1 | |
| SCHEMBL2932276 | 0.88 | CYP2D6 (0.41) | ADORA2AADORA1 | |
| SCHEMBL1760990 | 0.88 | PKM (0.41) | SMN1; SMN2 | |
| SCHEMBL2932137 | 0.88 | CCR3 (0.42) | GPR6HCAR1 | |
| SCHEMBL2930557 | 0.88 | HTT (0.38) | ADORA3ADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL2932222 | 0.86 | KDM4E (0.38) | GPR6ADORA3ADORA2AADORA1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |