Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930508 | 0.92 | GPR6 (0.34) | ADORA2AADORA3ADORA1 | |
| SCHEMBL2929411 | 0.92 | ADORA2A (0.41) | MAPK1ACHEBACE1MEN1KMT2A | |
| SCHEMBL2924971 | 0.91 | CCR3 (0.40) | LMNAACHEKDM4EALDH1A1 | |
| SCHEMBL3049811 | 0.91 | MEN1 (0.42) | LMNAMAPK1ACHEMEN1KMT2A | |
| SCHEMBL2932137 | 0.90 | CCR3 (0.42) | LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL2932222 | 0.88 | KDM4E (0.38) | MAPK1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2930506 | 0.88 | GPR6 (0.38) | LMNAACHEMEN1KMT2AALDH1A1 | |
| SCHEMBL1761028 | 0.87 | FAAH (0.47) | LMNAMAPK1GAAMAPTHPGD | |
| SCHEMBL2930504 | 0.86 | FAAH (0.45) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2931169 | 0.86 | OGA (0.38) | LMNAACHEMEN1KMT2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |