Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 11/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931914 | 0.91 | HCRTR2 (0.39) | HCRTR2HCRTR1MEN1POLBKMT2A | |
| SCHEMBL2928151 | 0.89 | HCRTR2 (0.35) | HCRTR2HCRTR1 | |
| SCHEMBL2924244 | 0.88 | CYP46A1 (0.39) | HCRTR2HCRTR1PIK3CD | |
| SCHEMBL2930074 | 0.88 | SLC6A7 (0.35) | HCRTR2HCRTR1GRM5PDE4B | |
| SCHEMBL2925368 | 0.87 | HCRTR1 (0.41) | HCRTR2HCRTR1 | |
| SCHEMBL2933639 | 0.86 | PAX8 (0.39) | — | |
| SCHEMBL2931039 | 0.85 | HCRTR2 (0.39) | HCRTR2HCRTR1HSD17B10GRM5PDE4B | |
| SCHEMBL3416000 | 0.85 | HCRTR1 (0.50) | HCRTR2HCRTR1GRM5 | |
| SCHEMBL2923507 | 0.85 | PAX8 (0.39) | HCRTR2HCRTR1 | |
| SCHEMBL2930955 | 0.85 | HCRTR2 (0.38) | HCRTR2HCRTR1POLBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | claimed |
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |