Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932351 | 0.90 | POLB (0.51) | ALDH1A1SMN1; SMN2MAPTL3MBTL1TDP1 | |
| SCHEMBL2924035 | 0.83 | LGMN (0.52) | ALDH1A1LMNAMAPTL3MBTL1HPGD | |
| SCHEMBL21001133 | 0.78 | CTSB (0.58) | ALDH1A1SMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL28461688 | 0.76 | FBP1 (0.59) | ALDH1A1SMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL19677556 | 0.75 | MAPT (0.70) | ALDH1A1SMN1; SMN2LMNAMAPTCYP2C9 | |
| SCHEMBL19030131 | 0.75 | MAPT (0.61) | ALDH1A1SMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL15486296 | 0.75 | NPC1 (0.77) | ALDH1A1SMN1; SMN2LMNAL3MBTL1NPC1 | |
| SCHEMBL940019 | 0.74 | PRKCZ (0.45) | ALDH1A1SMN1; SMN2LMNAMAPTCYP2C9 | |
| SCHEMBL15808259 | 0.73 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL14437127 | 0.73 | L3MBTL1 (0.43) | ALDH1A1SMN1; SMN2LMNAL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910314-B1 | BENZIMIDAZOLE DERIVATIVES FOR TREATMENT OF INFLAMMATORY DISEASES | NOVARTIS AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| US-20080306064-A1 | Benzimidazole Derivatives | BROWN LYNDON NIGEL | 2008-12-11 | — | — | US | disclosed |
| EP-1910314-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATMENT OF INFLAMMATORY DISEASES | Novartis AG (CH) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009774-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATMENT OF INFLAMMATORY DISEASES | NOVARTIS AG (CH) | 2007-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306064-A1 | Benzimidazole Derivatives | PPARG, PPARD, BRD4 | ALDH1A1 767/4885SMN1; SMN2 4540/4885LMNA 1938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.