SCHEMBL29314872

SCHEMBL29314872

CCOP(C)(=O)Cc1ccc(-c2cnc(N)c(NC(Cl)c3ccc4ncccc4c3)n2)cc1

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MET P08581 7/20 0.37
LDHB P07195 7/20 0.36
LDHA P00338 6/20 0.36
ATR Q13535 1/20 0.35
ACVR1 Q04771 1/20 0.34
HDAC1 Q13547 1/20 0.33
CLK1 P49759 2/20 0.33
ADORA2A P29274 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29314116 0.84 MET (0.41) METLDHBLDHAATR
SCHEMBL29314794 0.82 MET (0.39) METATRACVR1HDAC1
SCHEMBL29315062 0.81 MET (0.41) METATRACVR1HDAC1
SCHEMBL29314805 0.80 LDHB (0.48) METLDHBLDHAATRCLK1
SCHEMBL29317711 0.77 MET (0.41) METATRACVR1HDAC1
SCHEMBL29314878 0.77 MET (0.49) MET
SCHEMBL29314967 0.76 MET (0.37) METATRHDAC1
SCHEMBL22109370 0.76 MET (0.60) MET
SCHEMBL29314890 0.72 MET (0.39) METATRACVR1ADORA2A
SCHEMBL29314644 0.71 LDHA (0.43) METLDHBLDHAATR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3893872-B1 ORGANOPHOSPHORUS-SUBSTITUTED COMPOUNDS AS C-MET INHIBITORS AND THERAPEUTIC USES THEREOF BETA PHARMA INC (US) 2024-07-17 EP disclosed