Sugi Predict

Sugi Predict / Compounds / SCHEMBL29367884

SCHEMBL29367884

SCHEMBL29367884

COC(=O)c1cc2ccc(Cl)nc2n1C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.49
▸ KDM4E B2RXH2 3/20 0.44
▸ KMT2A Q03164 2/20 0.43
▸ CCR9 P51686 1/20 0.42
▸ ROCK1 Q13464 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ CYP11B2 P19099 1/20 0.38
▸ TUBB4A P04350 1/20 0.37
▸ TUBB P07437 1/20 0.37
▸ TUBA3C P0DPH7 1/20 0.37
▸ TUBA1B P68363 1/20 0.37
▸ TUBA4A P68366 1/20 0.37
▸ TUBB4B P68371 1/20 0.37
▸ TUBB3 Q13509 1/20 0.37
▸ TUBB2A Q13885 1/20 0.37
▸ TUBB8 Q3ZCM7 1/20 0.37
▸ TUBA3E Q6PEY2 1/20 0.37
▸ TUBA1A Q71U36 1/20 0.37
▸ TUBA1C Q9BQE3 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25207020 1.00 L3MBTL1 (0.49) L3MBTL1KDM4EKMT2ACCR9ROCK1
SCHEMBL27424598 0.84 ALOX15 (0.43) L3MBTL1KDM4EKMT2ACCR9MEN1
SCHEMBL31068635 0.83 L3MBTL1 (0.50) L3MBTL1KDM4EROCK1ALDH1A1F2
SCHEMBL29188992 0.83 CCR9 (0.54) KDM4ECCR9CYP11B2ALDH1A1HPGD
SCHEMBL29641122 0.79 CDK4 (0.41) L3MBTL1KMT2ACCR9MEN1CYP11B2
SCHEMBL24571282 0.79 CDK4 (0.41) L3MBTL1KMT2ACCR9MEN1CYP11B2
SCHEMBL20552536 0.78 L3MBTL1 (0.55) L3MBTL1KDM4EKMT2AMEN1RAB9A
SCHEMBL30988432 0.77 ROCK1 (0.63) L3MBTL1ROCK1
SCHEMBL27425388 0.77 ROCK1 (0.63) L3MBTL1ROCK1
SCHEMBL18938861 0.76 ROCK2 (0.47) L3MBTL1KMT2ACCR9ROCK1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260116879-A1 AZAINDOLE ROCK INHIBITORS AVICENNA BIOSCIENCES, INC. (US) 2026-04-30 — — US disclosed
EP-4642764-A2 AZAINDOLE ROCK INHIBITORS Avicenna Biosciences, Inc. (US) 2025-11-05 — — EP disclosed
US-12415805-B2 Azaindole rock inhibitors AVICENNA BIOSCIENCES, INC. (US) 2025-09-16 — — US disclosed
US-20250250273-A1 AZAINDOLE ROCK INHIBITORS AVICENNA BIOSCIENCES, INC. (US) 2025-08-07 — — US disclosed
US-12286433-B1 Azaindole rock inhibitors AVICENNA BIOSCIENCES, INC. (US) 2025-04-29 — — US disclosed
US-12281115-B2 Azaindole rock inhibitors AVICENNA BIOSCIENCES, INC. (US) 2025-04-22 — — US disclosed
US-20250115605-A1 AZAINDOLE ROCK INHIBITORS AVICENNA BIOSCIENCES, INC. (US) 2025-04-10 — — US disclosed
US-20250092038-A1 AZAINDOLE ROCK INHIBITORS AVICENNA BIOSCIENCES, INC. (US) 2025-03-20 — — US disclosed
US-12240848-B2 Azaindole rock inhibitors AVICENNA BIOSCIENCES, INC. (US) 2025-03-04 — — US disclosed
US-12116366-B2 Azaindole rock inhibitors AVICENNA BIOSCIENCES, INC. (US) 2024-10-15 — — US disclosed
US-20240254124-A1 AZAINDOLE ROCK INHIBITORS AVICENNA BIOSCIENCES, INC. (US) 2024-08-01 — — US disclosed
US-20240246972-A1 AZAINDOLE ROCK INHIBITORS AVICENNA BIOSCIENCES, INC. (US) 2024-07-25 — — US disclosed
WO-2024145569-A2 AZAINDOLE ROCK INHIBITORS AVICENNA BIOSCIENCES, INC. (US) 2024-07-04 — — WO disclosed
CN-116249531-A Compositions and methods for activating pyruvate kinase 密执安大学评议会 2023-06-09 — — CN disclosed
EP-4185293-A1 COMPOSITIONS AND METHODS FOR ACTIVATING PYRUVATE KINASE The Regents of The University of Michigan (US) 2023-05-31 — — EP disclosed
WO-2022020424-A1 COMPOSITIONS AND METHODS FOR ACTIVATING PYRUVATE KINASE THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2022-01-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12415805-B2 Azaindole rock inhibitors ROCK2, ROCK1, ARHGDIA L3MBTL1 1658/4885KDM4E 494/4885KMT2A 1053/4885
US-20250250273-A1 AZAINDOLE ROCK INHIBITORS ROCK2, ROCK1, ARHGDIA L3MBTL1 1658/4885KDM4E 494/4885KMT2A 1053/4885
US-12240848-B2 Azaindole rock inhibitors ROCK2, ROCK1, ARHGDIA L3MBTL1 1658/4885KDM4E 494/4885KMT2A 1053/4885
US-12281115-B2 Azaindole rock inhibitors ROCK2, ROCK1, ARHGDIA L3MBTL1 1658/4885KDM4E 494/4885KMT2A 1053/4885
US-20240254124-A1 AZAINDOLE ROCK INHIBITORS ROCK2, ROCK1, ARHGDIA L3MBTL1 1658/4885KDM4E 494/4885KMT2A 1053/4885
US-20260116879-A1 AZAINDOLE ROCK INHIBITORS PRKG2, PRKG1, ROCK2 L3MBTL1 4474/4885KDM4E 637/4885KMT2A 1024/4885
US-12116366-B2 Azaindole rock inhibitors ROCK2, ROCK1, ARHGDIA L3MBTL1 1658/4885KDM4E 494/4885KMT2A 1053/4885
US-20250115605-A1 AZAINDOLE ROCK INHIBITORS ROCK2, ROCK1, ARHGDIA L3MBTL1 1658/4885KDM4E 494/4885KMT2A 1053/4885
US-12286433-B1 Azaindole rock inhibitors ROCK2, ROCK1, ARHGDIA L3MBTL1 1658/4885KDM4E 494/4885KMT2A 1053/4885
US-20240246972-A1 AZAINDOLE ROCK INHIBITORS ROCK2, ROCK1, ARHGDIA L3MBTL1 1658/4885KDM4E 494/4885KMT2A 1053/4885
US-20250092038-A1 AZAINDOLE ROCK INHIBITORS ROCK2, ROCK1, ARHGDIA L3MBTL1 1658/4885KDM4E 494/4885KMT2A 1053/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.