SCHEMBL293752

SCHEMBL293752

[CH2]CCN1CCN(CC)CC1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.38
RAB9A P51151 1/20 0.38
SIGMAR1 Q99720 1/20 0.37
CHRNA7 P36544 1/20 0.37
KDM1A O60341 2/20 0.36
ALDH1A1 P00352 2/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
ALOX15 P16050 1/20 0.35
KDM4E B2RXH2 1/20 0.34
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
RAD52 P43351 1/20 0.34
GFER P55789 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
PKM P14618 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL387453 0.85
SCHEMBL10483535 0.85 ALOX15 (0.44) SIGMAR1ALDH1A1ALOX15KDM4ESMN1; SMN2
SCHEMBL1582630 0.84 KDM1A (0.40) MAPK1RAB9ASIGMAR1KDM1AALDH1A1
SCHEMBL294114 0.83 DRD2 (0.43) SIGMAR1ALOX15
SCHEMBL5391893 0.82 GNAI3 (0.42) MAPK1RAB9AKDM1AALDH1A1KDM4E
SCHEMBL6661360 0.82 KDM1A (0.45) MAPK1RAB9ASIGMAR1CHRNA7KDM1A
SCHEMBL6183476 0.82 CARM1 (0.40) SIGMAR1KDM4E
SCHEMBL6183469 0.82 GNAI3 (0.40) MAPK1RAB9AMEN1KMT2ASMN1; SMN2
SCHEMBL5390210 0.80 GNAI3 (0.45) KDM1AALDH1A1KDM4E
SCHEMBL5405364 0.80 GNAI3 (0.45) KDM1AALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3298011-B1 QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS PRINCIPIA BIOPHARMA INC (US) 2021-11-17 EP claimed
US-10294260-B2 Tetracyclic anthraquinone derivatives TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO., LTD. (CN) 2019-05-21 US claimed
US-20180155340-A1 QUINOLONE DERIVATIVES AS FGFR INHIBITORS PRINCIPIA BIOPHARMA INC. 2018-06-07 US claimed
EP-3298011-A1 QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS PRINCIPIA BIOPHARMA INC. (US) 2018-03-28 EP claimed
US-20170247403-A1 TETRACYCLIC ANTHRAQUINONE DERIVATIVES TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO LTD (CN) 2017-08-31 US claimed
US-9670242-B2 Tetracyclic anthraquinone derivatives TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO., LTD. (CN) 2017-06-06 US claimed
EP-2824108-B1 TETRACYCLIC ANTHRAQUINONE DERIVATIVES TIANJIN HEMAY BIO-TECH CO LTD (CN) 2017-04-19 EP claimed
WO-2016191172-A1 QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS PRINCIPIA BIOPHARMA INC. (US) 2016-12-01 WO claimed
US-20150166595-A1 Tetracyclic Anthraquinone Derivatives TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO., LTD. (CN) 2015-06-18 US claimed
EP-2824108-A1 TETRACYCLIC ANTHRAQUINONE DERIVATIVES Tianjin Hemay Bio-Tech Co., Ltd. (CN) 2015-01-14 EP claimed
US-6780996-B2 KINASE INHIBITORS; ANTICANCER AGENTS WYETH HOLDINGS CORPORATION 2004-08-24 US claimed
US-20040077681-A1 Pyrazolo[3,4-c]pyridines as gsk-3 inhibitors SMITHKLINE BEECHAM P.L.C (GB) 2004-04-22 US claimed
US-20040019052-A1 Pyrazolopyridines and pyrazolopyridazines as antidabetics SMITHKLINE BEECHAM P.L.C. (GB) 2004-01-29 US claimed
US-20030212276-A1 Process for the preparation of 7-substituted-3 quinolinecarbonitriles WYETH HOLDINGS CORPORATION 2003-11-13 US claimed
WO-2003093241-A1 PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-3-QUINOLINE AND 3-QUINOL-4-ONE CARBONITRILES WYETH HOLDINGS CORPORATION (US) 2003-11-13 WO claimed
WO-2003080617-A1 PYRAZOLOPYRIMIDINE DERIVATIVES GLAXO GROUP LIMITED (GB) 2003-10-02 WO claimed
EP-1347972-A1 PYRAZOLO 3,4-C]PYRIDINES AS GSK-3 INHIBITORS SMITHKLINE BEECHAM PLC (GB) 2003-10-01 EP claimed
EP-1319001-A1 PYRAZOLOPYRIDINES AND PYRAZOLOPYRIDAZINES AS ANTIDIABETICS SMITHKLINE BEECHAM PLC (GB) 2003-06-18 EP claimed
WO-2002050073-A1 PYRAZOLO[3,4-C]PYRIDINES AS GSK-3 INHIBITORS SMITHKLINE BEECHAM P.L.C. (GB) 2002-06-27 WO claimed
WO-2002024694-A1 PYRAZOLOPYRIDINES AND PYRAZOLOPYRIDAZINES AS ANTIDIABETICS SMITHKLINE BEECHAM, P.L.C. (GB) 2002-03-28 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180155340-A1 QUINOLONE DERIVATIVES AS FGFR INHIBITORS FGFR1, FGFR3, FGFR2 MAPK1 1681/4885RAB9A 1439/4885SIGMAR1 4745/4885
US-20150166595-A1 Tetracyclic Anthraquinone Derivatives ANTXR2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, TBXA2R MAPK1 3301/4885RAB9A 674/4885SIGMAR1 3686/4885
US-10294260-B2 Tetracyclic anthraquinone derivatives H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, F12, ANTXR2 MAPK1 2079/4885RAB9A 461/4885SIGMAR1 4369/4885
US-20030212276-A1 Process for the preparation of 7-substituted-3 quinolinecarbonitriles MAP4K2, MAP3K7, MAP4K1 MAPK1 116/4885RAB9A 958/4885SIGMAR1 3788/4885
US-20040077681-A1 Pyrazolo[3,4-c]pyridines as gsk-3 inhibitors GSK3B, GSK3A, GSKIP MAPK1 334/4885RAB9A 2085/4885SIGMAR1 1419/4885
US-20170247403-A1 TETRACYCLIC ANTHRAQUINONE DERIVATIVES ANTXR2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, TBXA2R MAPK1 3301/4885RAB9A 674/4885SIGMAR1 3686/4885
US-20040019052-A1 Pyrazolopyridines and pyrazolopyridazines as antidabetics PDXK, GCK, IAPP MAPK1 702/4885RAB9A 2207/4885SIGMAR1 860/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.