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ADAM12

Disintegrin and metalloproteinase domain-containing protein 12 · O43184 · ADAM12 on Sugi Atlas →

399 patent compounds predicted against ADAM12, 354 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Ilomastat Ilomastat (SCHEMBL35303) 1.00 1/20
Ilomastat Ilomastat (SCHEMBL4293696) 1.00 1/20
Ilomastat Ilomastat (SCHEMBL4394885) 1.00 1/20
Ilomastat Ilomastat (SCHEMBL6691646) 1.00 1/20
Ilomastat Ilomastat (SCHEMBL7870487) 1.00 1/20
Ilomastat Ilomastat (SCHEMBL8190117) 1.00 1/20
Ilomastat Ilomastat (SCHEMBL13575799) 1.00 1/20
Ilomastat Ilomastat (SCHEMBL29412562) 1.00 1/20
SCHEMBL8394283 SCHEMBL8394283 0.85 1/20
SCHEMBL4845965 SCHEMBL4845965 0.84 1/20
SCHEMBL5060570 SCHEMBL5060570 0.82 1/20
SCHEMBL5558468 SCHEMBL5558468 0.82 1/20
SCHEMBL6577793 SCHEMBL6577793 0.82 1/20
SCHEMBL7411594 SCHEMBL7411594 0.80 1/20
SCHEMBL24170626 SCHEMBL24170626 0.80 1/20
SCHEMBL851449 SCHEMBL851449 0.79 1/20
SCHEMBL6578096 SCHEMBL6578096 0.79 1/20
SCHEMBL8398105 SCHEMBL8398105 0.77 1/20
SCHEMBL24171226 SCHEMBL24171226 0.76 1/20
SCHEMBL24171241 SCHEMBL24171241 0.76 1/20

Clinical trials — most relevant to ADAM12 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY PHASE4SUSPENDED
Efficacy of Pioglitazone and Metformin on Cardiovascular Risk in Subjects With Insulin-Treated Type 2 Diabetes Mellitus. PHASE4COMPLETED
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast PHASE2COMPLETED
Tranexamic Acid (TXA) and Corona Virus 2019 (COVID19) in Inpatients PHASE2WITHDRAWN
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement PHASE1COMPLETED
Phase 1 Dose Escalation, Single Dose Study to Assess Safety and Pharmacokinetics of BAX930 in Hereditary Thrombotic Thrombocytopenic Purpura (TTP) PHASE1COMPLETED
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction nanCOMPLETED
Exercise and the Receptor for Advanced Glycation End Products (RAGE) nanCOMPLETED
Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1 nanUNKNOWN
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects nanAVAILABLE
Extracellular Matrix Remodeling of the Umbilical Cord and Placenta in Preeclampsia nanUNKNOWN
First-trimester Prediction of Preeclampsia nanCOMPLETED
Salivary Markers in Periodontal Disorders nanCOMPLETED
Association Between Matrix Metalloproteinase-2 Gene Polymorphism rs243865 and Susceptibility to Cataract Development nanCOMPLETED
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial nanCOMPLETED
Apoptotic Changes in Gingiva Caused by Smoking nanCOMPLETED
Peri-implantitis and MMP-8 nanCOMPLETED
ADAMTS-13 LEVEL AS PREDICTIVE BIOMARKER FOR DEVELOPMENT OF PORTAL VEIN THROMBOSIS IN LIVER CIRRHOSIS (ADAPTHRO) nanUNKNOWN
Infection, Sepsis and Meningitis in Surinamese Neonates nanCOMPLETED
Influence of Statins in Artery Aneurysms nanUNKNOWN
Pharmacokinetics of Low Molecular Weight Heparin in Cancer Patients nanCOMPLETED
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma nanUNKNOWN
Apoptosis Markers in Aggressive Periodontitis nanCOMPLETED
Role of Circulating MicroRNAs in Pathogenesis of Aneurysms of the Abdominal and Thoracic Aorta - Study Micro AAA nanUNKNOWN
Disorders of the Acute Phase Response Following Trauma and Invasive Surgery nanENROLLING_BY_INVITATION
Plasma Levels of Matrix Metalloproteinases (MMPs) and Degree of DNA Fragmentation in Pseudoexfoliation (PEX) Glaucoma nanCOMPLETED
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence nanWITHDRAWN
Influence of Short AV Delay Permanent Pacing on Matrix Metalloproteinase Levels nanCOMPLETED
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS nanCOMPLETED
Periodontal Health in Post COVID-19 Patients nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a ADAM12 binder may also engage these)

ProteinNameSimilarity
Q61824 — 1.000 Q61824 →
O35674 — 1.000 O35674 →
Q9H013 — 1.000 Q9H013 →
Q05910 — 0.994 Q05910 →
ADAM8 Disintegrin and metalloproteinase domain-containing protein 8 0.992 landscape →
Q8BNJ2 — 0.990 Q8BNJ2 →
P57110 — 0.988 P57110 →
Q8TE58 — 0.988 Q8TE58 →
ADAMTS1 A disintegrin and metalloproteinase with thrombospondin motifs 1 0.987 landscape →
P59511 — 0.987 P59511 →
P59384 — 0.986 P59384 →
Q4VC17 — 0.986 Q4VC17 →
Q9TT93 — 0.985 Q9TT93 →
Q69Z28 — 0.984 Q69Z28 →
P97857 — 0.984 P97857 →
Q13444 — 0.984 Q13444 →
Q9UKJ8 — 0.984 Q9UKJ8 →
Q9WUQ1 — 0.983 Q9WUQ1 →
Q63202 — 0.983 Q63202 →
Q9UKQ2 — 0.983 Q9UKQ2 →
Q8TE57 — 0.983 Q8TE57 →
Q9R159 — 0.983 Q9R159 →
ADAMTS5 A disintegrin and metalloproteinase with thrombospondin motifs 5 0.983 landscape →
ADAMTS7 A disintegrin and metalloproteinase with thrombospondin motifs 7 0.983 landscape →
Q9XSL6 — 0.982 Q9XSL6 →
P70505 — 0.982 P70505 →
Q5RFQ8 — 0.982 Q5RFQ8 →
Q9UKF2 — 0.981 Q9UKF2 →
Q68SA9 — 0.981 Q68SA9 →
P58459 — 0.981 P58459 →