Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.62 |
| ▸ | DRD4 | P21917 | 4/20 | 0.57 |
| ▸ | DRD3 | P35462 | 3/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22533031 | 1.00 | KDM4E (0.65) | KDM4EALDH1A1POLBTSHRHSD17B10 | |
| SCHEMBL13568797 | 0.89 | ALDH1A1 (0.71) | KDM4EALDH1A1POLBTSHRHSD17B10 | |
| SCHEMBL25672951 | 0.86 | KDM4E (0.63) | KDM4EALDH1A1POLBTSHRHSD17B10 | |
| SCHEMBL22532815 | 0.82 | ADRA1B (0.54) | KDM4EALDH1A1POLBTSHRHSD17B10 | |
| SCHEMBL8744970 | 0.81 | CACNA1G (0.57) | KDM4EALDH1A1POLBTSHRHSD17B10 | |
| SCHEMBL22533043 | 0.81 | GRM2 (0.54) | KDM4EALDH1A1POLBTSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL8745014 | 0.80 | CACNA1G (0.56) | KDM4EALDH1A1POLBTSHRHSD17B10 | |
| SCHEMBL11556492 | 0.80 | LMNA (0.59) | KDM4EALDH1A1POLBTSHRHSD17B10 | |
| SCHEMBL6751057 | 0.79 | KDM4E (0.61) | KDM4EALDH1A1POLBTSHRHSD17B10 | |
| SCHEMBL23102077 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1POLBTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4192450-A1 | ADVANTAGEOUS THERAPIES FOR DISORDERS MEDIATED BY IKAROS OR AIOLOS | C4 Therapeutics, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
| CN-116194438-A | Advantageous treatment of Ikaros or Aiolos mediated disorders | C4医药公司 | 2023-05-30 | — | — | CN | disclosed |
| WO-2022032132-A1 | ADVANTAGEOUS THERAPIES FOR DISORDERS MEDIATED BY IKAROS OR AIOLOS | C4 THERAPEUTICS, INC. (US) | 2022-02-10 | — | — | WO | disclosed |