Endomorphin 2

Endomorphin 2

SCHEMBL29387366

NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1

nearest known ligand 0.87

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 2/20 0.76
OPRD1 P41143 2/20 0.76
OPRK1 P41145 1/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Endomorphin 2 SCHEMBL29577635 1.00 OPRM1 (0.76) OPRM1OPRD1OPRK1
Endomorphin 2 SCHEMBL13252092 1.00 OPRM1 (0.76) OPRM1OPRD1OPRK1
Endomorphin 2 SCHEMBL22649436 1.00 OPRM1 (0.76) OPRM1OPRD1OPRK1
SCHEMBL38658663 0.96 OPRM1 (0.78) OPRM1OPRD1OPRK1
SCHEMBL31060785 0.94 OPRM1 (0.69) OPRM1OPRD1OPRK1
SCHEMBL29576785 0.94 SLC6A2 (0.74) OPRM1OPRD1OPRK1
SCHEMBL29577073 0.93 OPRM1 (0.67) OPRM1OPRD1OPRK1
Acetic Acid SCHEMBL11289266 0.93 OPRM1 (0.69) OPRM1OPRD1OPRK1
SCHEMBL30157193 0.92 OPRM1 (0.73) OPRM1OPRD1OPRK1
SCHEMBL23114234 0.91 OPRM1 (0.67) OPRM1OPRD1OPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 161 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118063557-A Hyaluronic acid modifier of cosmetic peptide and application thereof 杭州湃肽生化科技有限公司 2024-05-24 CN claimed
CN-117964700-A Novel transmembrane polypeptide with dual functions of easing pain and resisting anxiety 中国人民解放军空军军医大学 2024-05-03 CN claimed
CN-117050145-A Hyaluronic acid modifier of cosmetic peptide and application thereof 杭州湃肽生化科技有限公司 2023-11-14 CN claimed
CN-117050146-A Hyaluronic acid modified cosmetic peptide, preparation method and application thereof 杭州湃肽生化科技有限公司 2023-11-14 CN claimed
CN-116660543-A Diagnostic and prognostic markers for nonalcoholic fatty liver disease and uses thereof 中国人民解放军陆军军医大学第一附属医院 2023-08-29 CN claimed
EP-3795146-B1 PAIN-RELIEVING AND ANTI-INFLAMMATORY COMPOSITION FOR LOCAL USE AQMA ITALIA S P A (IT) 2023-06-07 EP claimed
CN-114096330-B Metal phase change compound and preparation method thereof 维白奥锤有限公司 2023-04-04 CN claimed
US-20220401430-A1 ALLOSTERIC MODULATORS OF THE MU OPIOID RECEPTOR Chiromics, LLC 2022-12-22 US claimed
US-11396453-B2 Metal compound having phase transformation and method of preparing the same WEBIOTREE CO.. LTD (KR) 2022-07-26 US claimed
CN-122094704-A Formulations for oral administration of active agents comprising a combination of acid-neutralizing polymer and non-polymeric material 2026-05-26 CN disclosed
WO-2026099555-A1 COSMETIC USE OF AN EXTRACT OF LYSIMACHIA CHRISTINAE BASF BEAUTY CARE SOLUTIONS FRANCE SAS (FR) 2026-05-15 WO disclosed
US-20260124143-A1 NEW PHARMACEUTICAL COMPOSITION FOR DRUG DELIVERY OREXO AB (SE) 2026-05-07 US disclosed
US-12617790-B2 Mitragynine analogs and uses thereof MEMORIAL SLOAN-KETTERING CANCER CENTER (US) 2026-05-05 US disclosed
US-20260115162-A1 COMPOSITION OR ASSOCIATION OF COMPOUNDS PREFERABLY FOR USE IN THE TREATMENT OF NERVOUS DISEASES IN PARTICULAR NEURODEGENERATIVE DISEASES, METHOD FOR THE PREPARATION OF SUCH COMPOSITION OR ASSOCIATION OF COMPOUNDS AND USES THEREOF PHARMACEUTICA SAN MARCO S R L (IT) 2026-04-30 US disclosed
EP-3962455-A1 NEW PHARMACEUTICAL COMPOSITION FOR DRUG DELIVERY Orexo AB (SE) 2022-03-09 EP disclosed
EP-3962928-A1 METHOD FOR TREATING OPIOID USE DISORDER The Administrators of The Tulane Educational Fund (US) 2022-03-09 EP disclosed
EP-3962510-A1 NOVEL SELECTIVE ACKR3 MODULATORS AND USES THEREOF Luxembourg Institute Of Health (LIH) (LU) 2022-03-09 EP disclosed
CN-114126615-A Opioid receptor antagonist prodrugs 尼萨姆实验室公司 2022-03-01 CN disclosed
US-20220056075-A1 METHOD FOR TREATING OPIOID USE DISORDER THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) 2022-02-24 US disclosed
US-11246873-B2 Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate THE SCRIPPS RESEARCH INSTITUTE (US) 2022-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12617790-B2 Mitragynine analogs and uses thereof OPRM1, OPRK1, OPRL1 OPRM1 1/4885OPRD1 4/4885OPRK1 2/4885
US-20220401430-A1 ALLOSTERIC MODULATORS OF THE MU OPIOID RECEPTOR OPRM1, OPRK1, OPRD1 OPRM1 1/4885OPRD1 3/4885OPRK1 2/4885
US-20260124143-A1 NEW PHARMACEUTICAL COMPOSITION FOR DRUG DELIVERY SLC5A1, SLC5A2, GLP1R OPRM1 2154/4885OPRD1 1267/4885OPRK1 2591/4885
US-20260115162-A1 COMPOSITION OR ASSOCIATION OF COMPOUNDS PREFERABLY FOR USE IN THE TREATMENT OF NERVOUS DISEASES IN PARTICULAR NEURODEGENERATIVE DISEASES, METHOD FOR THE PREPARATION OF SUCH COMPOSITION OR ASSOCIATION OF COMPOUNDS AND USES THEREOF HBZ, ALOX12, SNCA OPRM1 441/4885OPRD1 406/4885OPRK1 1788/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.