Histidine

Histidine

SCHEMBL29409456

N[C@@H](Cc1cnc[nH]1)C(=O)[O-].N[C@@H](Cc1cnc[nH]1)C(=O)[O-].[Cu+2]

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.71
SLC7A5 Q01650 1/20 0.71
HRH4 Q9H3N8 3/20 0.54
HRH3 Q9Y5N1 3/20 0.54
ALDH1A1 P00352 2/20 0.54
MEN1 O00255 1/20 0.54
GLA P06280 1/20 0.54
KMT2A Q03164 1/20 0.54
CYP1A2 P05177 1/20 0.54
NFKB1 P19838 1/20 0.54
THPO P40225 1/20 0.54
LMNA P02545 1/20 0.53
APEX1 P27695 1/20 0.53
BLM P54132 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL28403793 0.97 CYP3A4 (0.71) CYP3A4SLC7A5HRH4HRH3ALDH1A1
Histidine SCHEMBL30535770 0.97 CYP3A4 (0.71) CYP3A4SLC7A5HRH4HRH3ALDH1A1
Histidine SCHEMBL26659431 0.97 CYP3A4 (0.71) CYP3A4SLC7A5HRH4HRH3ALDH1A1
Histidine SCHEMBL30039286 0.97 CYP3A4 (0.71) CYP3A4SLC7A5HRH4HRH3ALDH1A1
Histidine SCHEMBL19974306 0.83 CYP3A4 (1.00) CYP3A4SLC7A5HRH4HRH3ALDH1A1
SCHEMBL5497653 0.83 CYP3A4 (0.75) CYP3A4SLC7A5HRH4HRH3ALDH1A1
Histidine SCHEMBL30852263 0.83 CYP3A4 (1.00) CYP3A4SLC7A5HRH4HRH3ALDH1A1
D-Histidine SCHEMBL288043 0.83 CYP3A4 (1.00) CYP3A4SLC7A5HRH4HRH3ALDH1A1
SCHEMBL5717709 0.83 CYP3A4 (0.75) CYP3A4SLC7A5HRH4HRH3ALDH1A1
Histidine SCHEMBL388560 0.83 CYP3A4 (1.00) CYP3A4SLC7A5HRH4HRH3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260041714-A1 CROSS-LINKING AGENTS AND ASSOCIATED METHODS UNIV UTAH RES FOUND (US) 2026-02-12 US claimed
US-12544400-B2 Treatment of myopic progression UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2026-02-10 US claimed
US-20240091255-A1 TREATMENT OF ASTIGMATISM IVEENA DELIVERY SYSTEMS, INC. 2024-03-21 US claimed
EP-4324454-A2 CROSS-LINKING AGENTS AND ASSOCIATED METHODS University of Utah Research Foundation (US) 2024-02-21 EP claimed
EP-4284392-A1 TREATMENT OF ASTIGMATISM Iveena Delivery Systems, Inc. (US) 2023-12-06 EP claimed
EP-3426262-B1 CROSS-LINKING AGENTS AND ASSOCIATED METHODS UNIV UTAH RES FOUND (US) 2023-08-23 EP claimed
US-20230256012-A1 TREATMENT OF MYOPIC PROGRESSION UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2023-08-17 US claimed
US-11524032-B2 Treatment of myopic progression UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2022-12-13 US claimed
US-20220288114-A1 MULTI-AGENT OCULAR FORMULATIONS AND TREATMENT METHODS UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2022-09-15 US claimed
CN-108431216-B Codon-optimized reduced size ATP7A CDNA and use for treating copper transport disorders 美国政府(由卫生和人类服务部的部长所代表) 2022-08-05 CN claimed
WO-2022165098-A1 TREATMENT OF ASTIGMATISM IVEENA DELIVERY SYSTEMS, INC. (US) 2022-08-04 WO claimed
EP-3996644-A1 MULTI-AGENT OCULAR FORMULATIONS AND TREATMENT METHODS University of Utah Research Foundation (US) 2022-05-18 EP claimed
US-20260137604-A1 COSMETIC COMPOSITIONS L'OREAL (FR) 2026-05-21 US disclosed
US-20260041714-A1 CROSS-LINKING AGENTS AND ASSOCIATED METHODS UNIV UTAH RES FOUND (US) 2026-02-12 US disclosed
US-12544400-B2 Treatment of myopic progression UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2026-02-10 US disclosed
US-20250388908-A1 METAL HOMEOSTASIS REGULATION WORCESTER POLYTECH INST (US) 2025-12-25 US disclosed
EP-3996644-A1 MULTI-AGENT OCULAR FORMULATIONS AND TREATMENT METHODS University of Utah Research Foundation (US) 2022-05-18 EP disclosed
EP-3981392-A1 CONTROLLED RELEASE DOSAGE FORM Triastek, Inc. (CN) 2022-04-13 EP disclosed
US-11278499-B2 Oral drug dosage form comprising various release profiles Triastek, Inc. (CN) 2022-03-22 US disclosed
US-20220054409-A1 RAPIDLY-ORODISPERSIBLE TABLETS HAVING AN INTERIOR CAVITY Aprecia Pharmaceuticals LLC 2022-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388908-A1 METAL HOMEOSTASIS REGULATION SLC39A14, SLC39A11, SLC39A3 CYP3A4 2454/4885SLC7A5 173/4885HRH4 4723/4885
US-20260041714-A1 CROSS-LINKING AGENTS AND ASSOCIATED METHODS KCNK17, KCNJ2, KCNK2 CYP3A4 3372/4885SLC7A5 1683/4885HRH4 4670/4885
US-11278499-B2 Oral drug dosage form comprising various release profiles CYP2D6, CYP3A7, CYP3A5 CYP3A4 4/4885SLC7A5 62/4885HRH4 1133/4885
US-20260137604-A1 COSMETIC COMPOSITIONS TYR, CUTA, LAGE3 CYP3A4 4034/4885SLC7A5 1105/4885HRH4 4023/4885
US-12544400-B2 Treatment of myopic progression LOXL1, LOXL3, LOXL2 CYP3A4 2783/4885SLC7A5 811/4885HRH4 4059/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.