Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300816 | 0.79 | HTR4 (0.54) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL4294891 | 0.78 | HTR4 (0.55) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| Maleic Acid SCHEMBL7299904 | 0.78 | HTR4 (0.50) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| Fumaric Acid SCHEMBL2942179 | 0.74 | HTR4 (0.51) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL2940563 | 0.73 | HTR4 (0.43) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL7307824 | 0.73 | HTR4 (0.49) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL7301718 | 0.72 | HTR4 (0.62) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL9704182 | 0.72 | HTR4 (0.63) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL4294889 | 0.71 | HTR4 (0.61) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| Fumaric Acid SCHEMBL7299906 | 0.70 | HTR4 (0.50) | HTR4CYP1A2CYP2C9ALOX15NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503764-B1 | 5-HT4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF HEART FAILURE | SERODUS AS (NO) | 2010-01-06 | — | — | EP | claimed |