SCHEMBL29416399

SCHEMBL29416399

COC(=O)c1ccc(Cl)nc1C(=O)OC

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 1/20 0.52
TUBB P07437 1/20 0.52
TUBA3C P0DPH7 1/20 0.52
TUBA1B P68363 1/20 0.52
TUBA4A P68366 1/20 0.52
TUBB4B P68371 1/20 0.52
TUBB3 Q13509 1/20 0.52
TUBB2A Q13885 1/20 0.52
TUBB8 Q3ZCM7 1/20 0.52
TUBA3E Q6PEY2 1/20 0.52
TUBA1A Q71U36 1/20 0.52
TUBA1C Q9BQE3 1/20 0.52
TUBB6 Q9BUF5 1/20 0.52
TUBB2B Q9BVA1 1/20 0.52
TUBB1 Q9H4B7 1/20 0.52
NPSR1 Q6W5P4 1/20 0.48
KDM4E B2RXH2 5/20 0.47
SMN1; SMN2 Q16637 4/20 0.46
L3MBTL1 Q9Y468 3/20 0.46
NPC1 O15118 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2527363 1.00 TUBB4A (0.52) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL25307810 0.89 TUBB4A (0.47) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL2527364 0.89 TUBB4A (0.47) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL30674849 0.89 TUBB4A (0.47) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29450481 0.83 TUBB4A (0.54) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL240027 0.83 ALDH1A1 (0.51) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29679379 0.83 ALDH1A1 (0.51) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL424747 0.83 TUBB4A (0.54) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL2211699 0.82 TSHR (0.47) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL3051920 0.81 TUBB4A (0.52) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250281424-A1 SMALL MOLECULE ANTAGONISTS OF PF4 ZHOU YUHANG (US) 2025-09-11 US disclosed
CN-115703776-B Plasmin inhibitor, preparation method and application thereof 赛诺哈勃药业(成都)有限公司 2025-06-17 CN disclosed
CN-119954801-A TAU protein targeting compounds and related methods of use 阿尔维纳斯运营股份有限公司 2025-05-09 CN disclosed
CN-114867727-B TAU protein targeting compounds and related methods of use 阿尔维纳斯运营股份有限公司 2025-02-21 CN disclosed
US-20240300986-A1 PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SCINNOHUB PHARMACEUTICAL CO., LTD (CN) 2024-09-12 US disclosed
CN-114245798-B CGRP antagonist compounds 奈克斯拉制药英国有限公司 2024-08-27 CN disclosed
CN-110891951-B Compounds of formula (I) 谢菲尔德大学 2024-08-20 CN disclosed
EP-3628045-B1 COMPOUNDS UNIV SHEFFIELD (GB) 2024-07-03 EP disclosed
US-20240124443-A1 PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF SCINNOHUB PHARMACEUTICAL CO., LTD (CN) 2024-04-18 US disclosed
CN-117545757-A 5-oxo-pyrido [2,3-d ] pyridazin-6 (5H) -ylacetamides 詹森药业有限公司 2024-02-09 CN disclosed
CN-117337288-A AXL inhibitor compounds 艾库斯生物科学有限公司 2024-01-02 CN disclosed
EP-4289850-A1 PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF Scinnohub Pharmaceutical Co., Ltd (CN) 2023-12-13 EP disclosed
EP-4273135-A1 PLASMIN INHIBITOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Scinnohub Pharmaceutical Co., Ltd (CN) 2023-11-08 EP disclosed
WO-2022166845-A1 PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 赛诺哈勃药业(成都)有限公司 2022-08-11 WO disclosed
CN-114867727-A TAU protein targeting compounds and related methods of use 阿尔维纳斯运营股份有限公司 2022-08-05 CN disclosed
US-11400081-B2 Compounds THE UNIVERSITY OF SHEFFIELD (GB) 2022-08-02 US disclosed
WO-2022143911-A1 PLASMIN INHIBITOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 赛诺哈勃药业(成都)有限公司 2022-07-07 WO disclosed
EP-3983416-A1 CGRP ANTAGONIST COMPOUNDS Heptares Therapeutics Limited (GB) 2022-04-20 EP disclosed
WO-2022073003-A1 SMALL MOLECULE ANTAGONISTS OF PF4 NEW YORK BLOOD CENTER, INC (US) 2022-04-07 WO disclosed
CN-114245798-A CGRP antagonist compounds 赫普泰雅治疗有限公司 2022-03-25 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250281424-A1 SMALL MOLECULE ANTAGONISTS OF PF4 PF4, F12, F2 TUBB4A 2219/4885TUBB 3468/4885TUBA3C 2788/4885
US-20240124443-A1 PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF F2, PLG, PLAT TUBB4A 4055/4885TUBB 3647/4885TUBA3C 3550/4885
US-20240300986-A1 PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF F2, PLG, PLAT TUBB4A 3974/4885TUBB 3489/4885TUBA3C 3582/4885
US-11400081-B2 Compounds MRGPRX2, MC2R, ADM2 TUBB4A 2941/4885TUBB 3310/4885TUBA3C 2425/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.