Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Indole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.44 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 7/20 | 0.94 |
| ▸ | CA1 | P00915 | 2/20 | 0.94 |
| ▸ | CA4 | P22748 | 2/20 | 0.94 |
| ▸ | CA6 | P23280 | 2/20 | 0.94 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.94 |
| ▸ | CA2 | P00918 | 1/20 | 0.94 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.94 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.94 |
| ▸ | ITGAL | P20701 | 1/20 | 0.94 |
| ▸ | ADK | P55263 | 1/20 | 0.94 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.45 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indole SCHEMBL4364385 | 1.00 | AHR (0.94) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL3538342 | 1.00 | AHR (0.94) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL29800701 | 0.97 | AHR (0.90) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL9215713 | 0.97 | AHR (0.90) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL9215718 | 0.97 | AHR (0.90) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL27455365 | 0.97 | AHR (0.90) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL30250492 | 0.97 | — | — | |
| Indole SCHEMBL29352896 | 0.97 | — | — | |
| Indole SCHEMBL30463845 | 0.97 | — | — | |
| Indole SCHEMBL698 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117627080-A | Deep water bridge pile foundation construction monitoring method and device | 广东省装饰有限公司 | 2024-03-01 | — | — | CN | claimed |
| CN-119464322-A | Application of yncJ gene in regulation and control of salmonella typhimurium virulence | 山东农业大学 | 2025-02-18 | — | — | CN | disclosed |
| CN-220748242-U | Pressure measuring device in drilling high-pressure water pressure test section | 浙江华东建设工程有限公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-117627080-A | Deep water bridge pile foundation construction monitoring method and device | 广东省装饰有限公司 | 2024-03-01 | — | — | CN | disclosed |
| EP-4308121-A1 | THERAPEUTIC CONJUGATES | Totus Medicines Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| EP-4210766-A1 | THERAPEUTIC CONJUGATES | Totus Medicines Inc. (US) | 2023-07-19 | — | — | EP | disclosed |
| EP-4211510-A1 | METHODS AND SYSTEMS FOR MAKING AN OPTICAL FUNCTIONAL FILM | Hsu, Roger Wen Yi (US) | 2023-07-19 | — | — | EP | disclosed |
| US-20230150215-A1 | METHODS AND SYSTEMS FOR MAKING AN OPTICAL FUNCTIONAL FILM | HSU ROGER WEN YI (US) | 2023-05-18 | — | — | US | disclosed |
| US-11541616-B2 | Methods and systems for making an optical functional film | HSU ROGER WEN YI (US) | 2023-01-03 | — | — | US | disclosed |
| WO-2022198024-A1 | THERAPEUTIC CONJUGATES | TOTUS MEDICINES INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| WO-2022056453-A1 | THERAPEUTIC CONJUGATES | TOTUS MEDICINES INC. (US) | 2022-03-17 | — | — | WO | disclosed |
| WO-2022055520-A1 | METHODS AND SYSTEMS FOR MAKING AN OPTICAL FUNCTIONAL FILM | HSU ROGER WEN YI (US) | 2022-03-17 | — | — | WO | disclosed |