Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Indole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.44 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 7/20 | 0.94 |
| ▸ | CA1 | P00915 | 2/20 | 0.94 |
| ▸ | CA4 | P22748 | 2/20 | 0.94 |
| ▸ | CA6 | P23280 | 2/20 | 0.94 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.94 |
| ▸ | CA2 | P00918 | 1/20 | 0.94 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.94 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.94 |
| ▸ | ITGAL | P20701 | 1/20 | 0.94 |
| ▸ | ADK | P55263 | 1/20 | 0.94 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.45 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indole SCHEMBL3538342 | 1.00 | AHR (0.94) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL29418271 | 1.00 | AHR (0.94) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL29800701 | 0.97 | AHR (0.90) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL9215713 | 0.97 | AHR (0.90) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL9215718 | 0.97 | AHR (0.90) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL27455365 | 0.97 | AHR (0.90) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL30250492 | 0.97 | — | — | |
| Indole SCHEMBL29352896 | 0.97 | — | — | |
| Indole SCHEMBL30463845 | 0.97 | — | — | |
| Indole SCHEMBL698 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108318949-A | A kind of plasmon exciton structure and its preparation method and application | 国家纳米科学中心 | 2018-07-24 | — | — | CN | claimed |
| CN-106133921-B | Transparent energy collection device | 密歇根州立大学董事会 | 2018-04-13 | — | — | CN | claimed |
| CN-106397297-A | Synthesis method of pindolol drug intermediate (-)-4-(2-hydroxy-3-isopropyl aminopropoxy)indole | 厦门安普顿信息科技有限公司 | 2017-02-15 | — | — | CN | claimed |
| CN-106133921-A | Transparent energy collecting device | 密歇根州立大学董事会 | 2016-11-16 | — | — | CN | claimed |
| CN-105461607-A | Synthetic method of pindolol medicine intermediate (I)-4-(2-hydroxyl-3-isopropyl amino propoxy)indole | CHENGDU KADIFU TECH CO LTD | 2016-04-06 | — | — | CN | claimed |
| CN-115867311-A | Polynucleotides comprising antigen cargo | 纳特科瑞克股份有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-108358921-B | Novel indole alkaloid compound and preparation method and application thereof | 海南师范大学 | 2020-09-04 | — | — | CN | disclosed |
| CN-110520128-A | Compositions and methods for treating complications and diseases associated with von Willebrand factor | BAND THERAPEUTICS LLC | 2019-11-29 | — | — | CN | disclosed |
| CN-110201187-A | Modified nucleosides, nucleotide and nucleic acid compositions | 现代泰克斯公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-105733364-B | A kind of aqueous near infrared absorption jetted ink and preparation method thereof | 北京印刷学院 | 2019-06-11 | — | — | CN | disclosed |
| CN-109422758-A | A kind of near-infrared fluorescent ratio fluorescent probe and its preparation method and application | 中国科学院深圳先进技术研究院 | 2019-03-05 | — | — | CN | disclosed |
| CN-109400584-A | A kind of fluorescence probe and its preparation method and application for tumour diagnosis and treatment | 中国科学院深圳先进技术研究院 | 2019-03-01 | — | — | CN | disclosed |
| CN-1558897-A | oral antidiabetic agent | ����-�����ع�˾ | 2004-12-29 | — | — | CN | disclosed |
| CN-1478078-A | Nitrogen-containing aromatic ring derivatives | ������������ʽ���� | 2004-02-25 | — | — | CN | disclosed |
| CN-1141773-A | Preparation of medicine containing 6-oxo-azitropilidene indole | KALI CHEMIE PHARMA GMBH (DE) | 1997-02-05 | — | — | CN | disclosed |
| EP-0558613-A1 | PYRIDOBENZOINDOLE DERIVATIVES, THEIR PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1993-09-08 | — | — | EP | disclosed |
| CN-1069733-A | 6-OXO-AZA * INDOLES, PROCESS FOR THEIR PRODUCTION, INTERMEDIATE PRODUCTS AND PHARMACEUTICAL APPLICATIONS | KALI CHEMIE PHARMA GMBH (DE) | 1993-03-10 | — | — | CN | disclosed |
| WO-1992009602-A1 | PYRIDOBENZOINDOLE DERIVATIVES, THEIR PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1992-06-11 | — | — | WO | disclosed |
| EP-0402232-A1 | Pyridobenzoindole derivatives, their preparation and compositions containing them | RHONE-POULENC SANTE (FR) | 1990-12-12 | — | — | EP | disclosed |
| US-3954799-A | Protonated indole phthalides and naphthalides | POLAROID CORPORATION (US) | 1976-05-04 | — | — | US | disclosed |