Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.57 |
| ▸ | SNCA | P37840 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.55 |
| ▸ | TERT | O14746 | 1/20 | 0.54 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.54 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12937374 | 0.92 | TOP1 (0.74) | TOP1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL823156 | 0.88 | RAB9A (0.75) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1250809 | 0.86 | RAB9A (0.60) | TOP1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL29429233 | 0.86 | TOP1 (0.89) | TOP1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL109009 | 0.86 | TOP1 (0.89) | TOP1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL25815389 | 0.83 | NPC1 (0.72) | TOP1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL2917616 | 0.83 | FKBP5 (0.73) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13400967 | 0.82 | RAB9A (0.67) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1249104 | 0.82 | KMT2A (0.63) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14350091 | 0.81 | RAB9A (0.65) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919530-B2 | Compounds, compositions, and methods for the treatment of synucleinopathies | PROTEOTECH, INC. (US) | 2011-04-05 | — | — | US | disclosed |
| US-7919530-B2 | Compounds, compositions, and methods for the treatment of synucleinopathies | PROTEOTECH, INC. (US) | 2011-04-05 | — | — | US | disclosed |
| US-20100179223-A1 | Compounds, Compositions, and Methods for the Treatment of Synucleinopathies | PROTAMED, INC. | 2010-07-15 | — | — | US | disclosed |
| US-20100179223-A1 | Compounds, Compositions, and Methods for the Treatment of Synucleinopathies | PROTAMED, INC. | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179223-A1 | Compounds, Compositions, and Methods for the Treatment of Synucleinopathies | SNCA, PARK7, COMT | TOP1 2527/4885RAB9A 393/4885NPC1 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.