Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.49 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.49 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.49 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.49 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 5/20 | 0.55 |
| ▸ | TSPO | P30536 | 1/20 | 0.54 |
| ▸ | FABP4 | P15090 | 3/20 | 0.53 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.53 |
| ▸ | FABP3 | P05413 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL23927875 | 1.00 | HTR7 (0.55) | HTR7TSPOFABP4FABP5FABP3 | |
| SCHEMBL11826363 | 0.85 | CYP2D6 (0.59) | FABP4FABP5FABP3HTR6ALDH1A1 | |
| SCHEMBL18919091 | 0.83 | HTR6 (0.56) | HTR7TSPOHTR6ALDH1A1CYP1A2 | |
| SCHEMBL18919088 | 0.83 | HTR6 (0.56) | HTR7TSPOHTR6ALDH1A1CYP1A2 | |
| Fumaric Acid SCHEMBL29435349 | 0.79 | ALDH1A1 (0.62) | HTR7HTR6ALDH1A1CYP1A2POLB | |
| Fumaric Acid SCHEMBL23927914 | 0.79 | ALDH1A1 (0.62) | HTR7HTR6ALDH1A1CYP1A2POLB | |
| SCHEMBL10704467 | 0.79 | ALDH1A1 (0.59) | HTR6ALDH1A1CYP1A2POLBSLC6A2 | |
| Fumaric Acid SCHEMBL23927880 | 0.76 | HTR7 (0.73) | HTR7HTR6HTR2AHTR2CHTR1A | |
| Fumaric Acid SCHEMBL29435346 | 0.76 | HTR7 (0.73) | HTR7HTR6HTR2AHTR2CHTR1A | |
| Fumaric Acid SCHEMBL23927822 | 0.75 | HTR2C (0.75) | HTR7ALDH1A1CYP1A2POLBHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220251040-A1 | N-SUBSTITUTED INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-08-11 | — | — | US | disclosed |
| US-11254640-B2 | N-substituted indoles and other heterocycles for treating brain disorders | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11254640-B2 | N-substituted indoles and other heterocycles for treating brain disorders | TPH2, AANAT, HTR2C | SLC6A2 27/4885HTR2A 5/4885HTR2C 3/4885 |
| US-20220251040-A1 | N-SUBSTITUTED INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS | TPH2, AANAT, HTR2C | SLC6A2 27/4885HTR2A 5/4885HTR2C 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.