Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15895653 | 0.75 | — | — | |
| SCHEMBL12434773 | 0.73 | — | — | |
| SCHEMBL23829518 | 0.73 | — | — | |
| SCHEMBL23697199 | 0.73 | — | — | |
| SCHEMBL22879747 | 0.71 | — | — | |
| SCHEMBL24982602 | 0.69 | — | — | |
| SCHEMBL10000293 | 0.65 | — | — | |
| SCHEMBL541691 | 0.63 | GABRR1 (0.46) | ENPEPTP53 | |
| SCHEMBL28466934 | 0.63 | CA1 (0.31) | — | |
| SCHEMBL786927 | 0.62 | ENPEP (0.50) | TDP1OR51E2ALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7785616-B2 | C-nitroso compounds and use thereof | DUKE UNIVERSITY (US) | 2010-08-31 | — | — | US | disclosed |
| US-20070258942-A1 | C-Nitroso compounds and use thereof | DUKE UNIVERSITY (US) | 2007-11-08 | — | — | US | disclosed |
| US-7259250-B2 | C-nitroso compounds and use thereof | DUKE UNIVERSITY (US) | 2007-08-21 | — | — | US | disclosed |
| EP-1330425-B1 | C-NITROSO COMPOUNDS AND USE THEREOF | UNIV DUKE (US) | 2007-06-13 | — | — | EP | disclosed |
| US-7049308-B2 | C-nitroso compounds and use thereof | DUKE UNIVERSITY (US) | 2006-05-23 | — | — | US | disclosed |
| US-7030238-B2 | C-nitroso compounds and use thereof | DUKE UNIVERSITY (US) | 2006-04-18 | — | — | US | disclosed |
| US-20050203295-A1 | C-nitroso compounds and use thereof | DUKE UNIVERSITY (US) | 2005-09-15 | — | — | US | disclosed |
| US-20050187166-A1 | C-nitroso compounds and use thereof | DUKE UNIVERSITY (US) | 2005-08-25 | — | — | US | disclosed |
| US-6887994-B2 | Such as dimeric 2-(4'-(alpha-nitroso)isobutyrylphenyl) propionic acid formed by nitrosylation of carbon acid; useful as nitrogen oxide donor; for treating pain/inflammation | DUKE UNIVERSITY (US) | 2005-05-03 | — | — | US | disclosed |
| US-20040006059-A1 | C-nitroso compounds and use thereof | DUKE UNIVERSITY | 2004-01-08 | — | — | US | disclosed |
| US-20030176668-A1 | C-nitroso compounds and use thereof | STAMLER JONATHAN S (US) | 2003-09-18 | — | — | US | disclosed |
| EP-1330425-A2 | C-NITROSO COMPOUNDS AND USE THEREOF | DUKE UNIVERSITY (US) | 2003-07-30 | — | — | EP | disclosed |
| US-6538116-B2 | For therapy of inflammatory or painful disorder | DUKE UNIVERSITY | 2003-03-25 | — | — | US | disclosed |
| US-20020077506-A1 | For therapy of inflammatory or painful disorder | STAMLER JONATHAN S (US) | 2002-06-20 | — | — | US | disclosed |
| WO-2002034705-A2 | C-NITROSO COMPOUNDS AND USE THEREOF | DUKE UNIVERSITY (US) | 2002-05-02 | — | — | WO | disclosed |
| US-6359182-B1 | VASCULAR SYSTEM RELAXATION; ANTIINFLAMMATORY AGENTS; ANALGESICS | DUKE UNIVERSITY | 2002-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187166-A1 | C-nitroso compounds and use thereof | NOS2, NOS3, PRKG1 | TDP1 2075/4885OR51E2 1878/4885ALDH1A1 542/4885 |
| US-20020077506-A1 | For therapy of inflammatory or painful disorder | PTGS1, PTGS2, PTGER1 | TDP1 3000/4885OR51E2 1392/4885ALDH1A1 321/4885 |
| US-20050203295-A1 | C-nitroso compounds and use thereof | PTGS1, NOS1, NOS2 | TDP1 2837/4885OR51E2 2188/4885ALDH1A1 271/4885 |
| US-20070258942-A1 | C-Nitroso compounds and use thereof | NOS3, PRKG1, NOS1 | TDP1 2433/4885OR51E2 1134/4885ALDH1A1 690/4885 |
| US-20040006059-A1 | C-nitroso compounds and use thereof | NOS2, NOS3, NOS1 | TDP1 1971/4885OR51E2 2111/4885ALDH1A1 596/4885 |
| US-20030176668-A1 | C-nitroso compounds and use thereof | PTGS1, NOS1, NOS2 | TDP1 2760/4885OR51E2 2470/4885ALDH1A1 327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.