Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | P4HB | P07237 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451601 | 0.86 | SMN1; SMN2 (0.38) | HSD17B10MAPK1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4575361 | 0.79 | FBP1 (0.44) | MAPK1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4575360 | 0.79 | FBP1 (0.44) | MAPK1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6359890 | 0.78 | NR1H3 (0.33) | ALDH1A1SMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL4843078 | 0.77 | L3MBTL1 (0.42) | ALDH1A1SMN1; SMN2RAB9AKMT2ANR1H3 | |
| SCHEMBL4843067 | 0.77 | L3MBTL1 (0.42) | ALDH1A1SMN1; SMN2RAB9AKMT2ANR1H3 | |
| SCHEMBL20299500 | 0.76 | TUBB4A (0.49) | MAPK1SLC7A5ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4841559 | 0.76 | CYSLTR2 (0.44) | ALDH1A1SMN1; SMN2RAB9AKMT2ANR1H3 | |
| SCHEMBL4841552 | 0.76 | CYSLTR2 (0.44) | ALDH1A1SMN1; SMN2RAB9AKMT2ANR1H3 | |
| SCHEMBL6925031 | 0.75 | KDM4E (0.50) | HSD17B10MAPK1SLC7A5ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |