Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 8/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | MITF | O75030 | 2/20 | 0.40 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451784 | 0.86 | PRMT5 (0.44) | PRMT5WDR77MAPTRAB9APAX8 | |
| SCHEMBL29451404 | 0.85 | RAB9A (0.55) | PRMT5WDR77MAPTKMT2AMEN1 | |
| SCHEMBL29451540 | 0.81 | FPR1 (0.35) | PRMT5WDR77MAPTRAB9ANPC1 | |
| SCHEMBL29451308 | 0.79 | RAB9A (0.57) | PRMT5WDR77MAPTKMT2AMEN1 | |
| SCHEMBL29451486 | 0.76 | PRMT5 (0.47) | PRMT5WDR77MAPTKMT2AMEN1 | |
| SCHEMBL29452153 | 0.71 | PRMT5 (0.35) | PRMT5WDR77MAPTRAB9ANPC1 | |
| SCHEMBL29452230 | 0.69 | PRMT5 (0.45) | PRMT5WDR77MAPTRAB9APAX8 | |
| SCHEMBL29451727 | 0.69 | PRMT5 (0.45) | PRMT5WDR77MAPTRAB9APAX8 | |
| SCHEMBL29451928 | 0.65 | KDM4E (0.45) | PRMT5WDR77MAPTRAB9ANPC1 | |
| SCHEMBL29451586 | 0.60 | ABCC8 (0.44) | MAPTL3MBTL1KDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |