Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452047 | 0.86 | PRMT5 (0.47) | PRMT5WDR77NPC1MITFRAB9A | |
| SCHEMBL29451404 | 0.83 | RAB9A (0.55) | PRMT5WDR77NPC1MITFRAB9A | |
| SCHEMBL29452153 | 0.81 | PRMT5 (0.35) | PRMT5WDR77NPC1RAB9AMAPT | |
| SCHEMBL29451308 | 0.79 | RAB9A (0.57) | PRMT5WDR77NPC1MITFRAB9A | |
| SCHEMBL29451485 | 0.72 | PRMT5 (0.46) | PRMT5WDR77NPC1MITFRAB9A | |
| SCHEMBL29451540 | 0.71 | FPR1 (0.35) | PRMT5WDR77NPC1RAB9AMAPT | |
| SCHEMBL29452230 | 0.67 | PRMT5 (0.45) | PRMT5WDR77NPC1MITFRAB9A | |
| SCHEMBL29451753 | 0.66 | PRMT5 (0.68) | PRMT5WDR77NPC1MITFRAB9A | |
| SCHEMBL29451417 | 0.63 | KMO (0.44) | PRMT5WDR77MAPTALDH1A1KDM4E | |
| SCHEMBL29451586 | 0.62 | ABCC8 (0.44) | MAPTALDH1A1KDM4EL3MBTL1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |