Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | TACR2 | P21452 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7172701 | 0.76 | TRPA1 (0.33) | TP53PTGS1PTGS2 | |
| SCHEMBL6245853 | 0.72 | HSD11B1 (0.39) | ALDH1A1HSD17B10SMN1; SMN2TP53NPC1 | |
| SCHEMBL24038424 | 0.71 | KDM4E (0.36) | ALDH1A1SMN1; SMN2TP53KDM4ELMNA | |
| SCHEMBL329514 | 0.71 | CA2 (0.58) | SKP2CA2CA1ALDH1A1HPGD | |
| SCHEMBL83869 | 0.68 | CA2 (0.65) | SKP2CA2CA1ALDH1A1HPGD | |
| SCHEMBL1187465 | 0.67 | HPGD (0.54) | SKP2CA2CA1ALDH1A1HPGD | |
| SCHEMBL9839955 | 0.66 | CA2 (0.62) | SKP2CA2CA1ALDH1A1HPGD | |
| SCHEMBL10568421 | 0.66 | ALDH1A1 (0.65) | CA2CA1ALDH1A1HPGDHSD17B10 | |
| Ammonia Solution, Strong SCHEMBL28990998 | 0.66 | CA2 (0.62) | SKP2CA2CA1ALDH1A1HPGD | |
| SCHEMBL7513802 | 0.66 | RARB (0.60) | CA2CA1ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101312973-B | Indolizine derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI-AVENTIS (FR) | 2011-12-28 | — | — | CN | disclosed |
| US-7799799-B2 | Indolizine derivatives, method for preparing same, and therapeutic compositions comprising same | SANOFI-AVENTIS (FR) | 2010-09-21 | — | — | US | disclosed |
| EP-1957490-B1 | NOVEL INDOLIZINE DERIVATIVES, METHOD FOR PREPARING SAME AND THERAPEUTIC COMPOSITIONS COMPRISING SAME | SANOFI AVENTIS (FR) | 2010-01-06 | — | — | EP | disclosed |
| CN-101312973-A | Indolizine derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI AVENTIS (FR) | 2008-11-26 | — | — | CN | disclosed |
| US-20080287485-A1 | NOVEL INDOLIZINE DERIVATIVES, METHOD FOR PREPARING SAME, AND THERAPEUTIC COMPOSITIONS COMPRISING SAME | SANOFI-AVENTIS (FR) | 2008-11-20 | — | — | US | disclosed |
| EP-1957490-A1 | NOVEL INDOLIZINE DERIVATIVES, METHOD FOR PREPARING SAME AND THERAPEUTIC COMPOSITIONS COMPRISING SAME | sanofi-aventis (FR) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007060318-A1 | NOVEL INDOLIZINE DERIVATIVES, METHOD FOR PREPARING SAME AND THERAPEUTIC COMPOSITIONS COMPRISING SAME | SANOFI-AVENTIS (FR) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287485-A1 | NOVEL INDOLIZINE DERIVATIVES, METHOD FOR PREPARING SAME, AND THERAPEUTIC COMPOSITIONS COMPRISING SAME | INMT, IDO1, IDO2 | SKP2 834/4885CA2 3001/4885CA1 2685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.