Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 4/20 | 0.56 |
| ▸ | POR | P16435 | 4/20 | 0.56 |
| ▸ | IDO1 | P14902 | 10/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 3/20 | 0.37 |
| ▸ | BLM | P54132 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (3R)-Dunnione SCHEMBL29468606 | 0.88 | NQO1 (0.63) | NQO1PORIDO1AKT1ELANE | |
| (3R)-Dunnione SCHEMBL103115 | 0.88 | NQO1 (0.63) | NQO1PORIDO1AKT1ELANE | |
| (3R)-Dunnione SCHEMBL6052903 | 0.82 | NQO1 (0.56) | NQO1PORIDO1AKT1ELANE | |
| SCHEMBL8260282 | 0.81 | NQO1 (0.52) | NQO1PORIDO1AKT1ELANE | |
| SCHEMBL6052838 | 0.74 | NQO1 (0.57) | NQO1PORIDO1AKT1ELANE | |
| (3R)-Dunnione SCHEMBL8535310 | 0.73 | NQO1 (0.47) | NQO1PORIDO1MEN1KMT2A | |
| SCHEMBL3329489 | 0.72 | NQO1 (0.50) | NQO1PORIDO1ELANEMEN1 | |
| SCHEMBL3331249 | 0.72 | NQO1 (0.50) | NQO1PORIDO1ELANEMEN1 | |
| SCHEMBL6052899 | 0.69 | NQO1 (0.67) | NQO1PORIDO1ELANEKDM4E | |
| SCHEMBL10353380 | 0.68 | DNMT3B (0.40) | NQO1PORKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888326-B1 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RES FOUND (US) | 2006-08-16 | — | — | EP | claimed |
| JP-2000506841-A | — | — | 2000-06-06 | — | — | JP | claimed |
| EP-0888326-A2 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-01-07 | — | — | EP | claimed |
| WO-1997031936-A2 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1997-09-04 | — | — | WO | claimed |
| CN-121181506-A | Alpha-Dunnione analogue, preparation method and application thereof | 西华大学 | 2025-12-23 | — | — | CN | disclosed |
| CN-121181506-A | Alpha-Dunnione analogue, preparation method and application thereof | 西华大学 | 2025-12-23 | — | — | CN | disclosed |
| EP-3284464-B1 | COMPOSITION FOR PREVENTING AND TREATING PANCREATITIS CONTAINING NAPHTHOQUINONE-BASED COMPOUND AS ACTIVE INGREDIENT | NADIANBIO LTD (KR) | 2025-08-13 | — | — | EP | disclosed |
| US-12370170-B2 | Composition comprising naphthoquinone-based compound as active ingredient, for preventing or ameliorating fatigue, cachexia, pain, cognitive decline and hematopoietic stem cell reduction which are side effects related to anticancer drug treatment | NADIANBIO LTD. (KR) | 2025-07-29 | — | — | US | disclosed |
| US-20250170252-A1 | QUINONE PROTECTED FORMS AND CONJUGATES | CAMBRIDGE ENTERPRISE LIMITED (GB) | 2025-05-29 | — | — | US | disclosed |
| EP-3449920-B1 | COMPOSITION COMPRISING DUNNIONE OR BETA-LAPACHONE AS ACTIVE INGREDIENT, FOR PREVENTING OR AMELIORATING FATIGUE, PAIN, COGNITIVE DECLINE AND HEMATOPOIETIC STEM CELL REDUCTION WHICH ARE SIDE EFFECTS RELATED TO ANTICANCER DRUG TREATMENT | NADIANBIO LTD (KR) | 2025-05-28 | — | — | EP | disclosed |
| EP-4532480-A1 | QUINONE PROTECTED FORMS AND CONJUGATES | Cambridge Enterprise Limited (GB) | 2025-04-09 | — | — | EP | disclosed |
| US-12257230-B2 | Composition comprising naphthoquinone-based compound as active ingredient, for preventing or ameliorating fatigue, cachexia, pain, cognitive decline and hematopoietic stem cell reduction which are side effects related to anticancer drug treatment | NADIANBIO LTD. (KR) | 2025-03-25 | — | — | US | disclosed |
| EP-0888326-B1 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RES FOUND (US) | 2006-08-16 | — | — | EP | disclosed |
| EP-1567515-A2 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2005-08-31 | — | — | EP | disclosed |
| US-20040266857-A1 | Novel lapachone compounds and methods of use thereof | HINES GLOBAL EDUCATION | 2004-12-30 | — | — | US | disclosed |
| WO-2004045557-A2 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2004-06-03 | — | — | WO | disclosed |
| US-5969163-A | CONTACTING SOLUTION OF LAWSONE IN DIMETHYL SULFOXIDE AT LOW TEMPERATURE WITH LITHIUM HYDRIDE AND WARMING TO FORM LITHIUM SALT, ALKYLATING WITH ALLYL HALIDE IN PRESENCE OF LITHIUM IODIDE, CYCLIZING ALKYLATED LAWSONE DERIVATIVES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0888326-A2 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-01-07 | — | — | EP | disclosed |
| US-5824700-A | ANTICARCINOGENIC AGENTS FOR TREATING BREAST CANCER OR COLON CANCER | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1998-10-20 | — | — | US | disclosed |
| WO-1997031936-A2 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1997-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12257230-B2 | Composition comprising naphthoquinone-based compound as active ingredient, for preventing or ameliorating fatigue, cachexia, pain, cognitive decline and hematopoietic stem cell reduction which are side effects related to anticancer drug treatment | IL17A, ACHE, IL1B | NQO1 5/4885POR 1360/4885IDO1 1918/4885 |
| US-20040266857-A1 | Novel lapachone compounds and methods of use thereof | XIAP, MKI67, PIN1 | NQO1 4/4885POR 2496/4885IDO1 1021/4885 |
| US-12370170-B2 | Composition comprising naphthoquinone-based compound as active ingredient, for preventing or ameliorating fatigue, cachexia, pain, cognitive decline and hematopoietic stem cell reduction which are side effects related to anticancer drug treatment | ACHE, NES, GSTO1 | NQO1 11/4885POR 2987/4885IDO1 3195/4885 |
| US-20250170252-A1 | QUINONE PROTECTED FORMS AND CONJUGATES | NQO1, SQOR, GSTP1 | NQO1 1/4885POR 198/4885IDO1 932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.