Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14236914 | 0.85 | ALDH1A1 (0.44) | ALDH1A1HPGDHTTSMN1; SMN2TLR2 | |
| SCHEMBL28323985 | 0.81 | LIPG (0.40) | ALDH1A1TSHRLMNAKCNJ1MEN1 | |
| SCHEMBL8981378 | 0.78 | ALDH1A1 (0.42) | ALDH1A1HPGDHTTSMN1; SMN2TLR2 | |
| SCHEMBL30529905 | 0.78 | ESR1 (0.38) | ALDH1A1HTTSMN1; SMN2TYMSLMNA | |
| SCHEMBL12760683 | 0.76 | ALDH1A1 (0.41) | ALDH1A1HPGDHTTSMN1; SMN2TLR2 | |
| SCHEMBL548566 | 0.75 | ALDH1A1 (0.46) | ALDH1A1HPGDHTTSMN1; SMN2TLR2 | |
| SCHEMBL1200782 | 0.74 | ALDH1A1 (0.47) | ALDH1A1HPGDHTTSMN1; SMN2TLR2 | |
| SCHEMBL5434859 | 0.72 | ALDH1A1 (0.59) | ALDH1A1HPGDHTTSMN1; SMN2TLR2 | |
| SCHEMBL8759951 | 0.72 | ALDH1A1 (0.35) | ALDH1A1TSHRLMNAKCNJ1MEN1 | |
| SCHEMBL6527128 | 0.72 | BACE1 (0.38) | ALDH1A1HPGDHTTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754727-B2 | 4-phenylpiperidine derivatives as renin inhibitors | NOVARTIS AG (CH) | 2010-07-13 | — | — | US | disclosed |
| US-20080269255-A1 | 4-Phenylpiperidine Derivatives as Renin Inhibitors | NOVARTIS AG (CH) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269255-A1 | 4-Phenylpiperidine Derivatives as Renin Inhibitors | REN, AGTR1, ACE | ALDH1A1 417/4885HPGD 230/4885HTT 2227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.