Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 11/20 | 0.60 |
| ▸ | CTSK | P43235 | 11/20 | 0.60 |
| ▸ | CTSL | P07711 | 10/20 | 0.60 |
| ▸ | CTSS | P25774 | 3/20 | 0.60 |
| ▸ | CTSF | Q9UBX1 | 8/20 | 0.53 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948349 | 1.00 | CTSB (0.60) | CTSBCTSKCTSLCTSSCTSF | |
| SCHEMBL17585395 | 0.87 | CTSB (0.57) | CTSBCTSKCTSLCTSSCTSF | |
| SCHEMBL24199878 | 0.87 | CTSL (0.78) | CTSBCTSKCTSLCTSSCTSF | |
| SCHEMBL24199833 | 0.87 | CTSB (0.63) | CTSBCTSKCTSLCTSSCTSF | |
| SCHEMBL12679262 | 0.86 | CTSB (0.48) | CTSBCTSKCTSLCTSSCTSF | |
| SCHEMBL2947331 | 0.85 | CTSL (0.64) | CTSBCTSKCTSLCTSSCTSF | |
| SCHEMBL2947335 | 0.85 | CTSL (0.64) | CTSBCTSKCTSLCTSSCTSF | |
| SCHEMBL21690134 | 0.84 | CTSK (0.65) | CTSBCTSKCTSLCTSSCTSF | |
| SCHEMBL21645298 | 0.84 | CTSK (0.65) | CTSBCTSKCTSLCTSSCTSF | |
| SCHEMBL3762636 | 0.84 | CTSK (0.65) | CTSBCTSKCTSLCTSSCTSF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225196-B1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES | MERCK CANADA INC (CA) | 2015-01-28 | — | — | EP | claimed |
| US-20100305056-A1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASE | MERCK FROSST CANADA LTD. (CA) | 2010-12-02 | — | — | US | claimed |
| EP-2225196-A1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES | Merck Frosst Canada Ltd. (CA) | 2010-09-08 | — | — | EP | claimed |
| WO-2009067797-A1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES | MERCK FROSST CANADA LTD. (CA) | 2009-06-04 | — | — | WO | claimed |
| EP-3720840-B1 | CATHEPSIN INHIBITORS | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2022-01-19 | — | — | EP | disclosed |
| US-11174224-B2 | Cathepsin inhibitors | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2021-11-16 | — | — | US | disclosed |
| US-20200385341-A1 | CATHEPSIN INHIBITORS | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2020-12-10 | — | — | US | disclosed |
| EP-2225196-B1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES | MERCK CANADA INC (CA) | 2015-01-28 | — | — | EP | disclosed |
| US-8642799-B2 | Cysteine protease inhibitors for the treatment of parasitic diseases | MERCK CANADA INC. (CA) | 2014-02-04 | — | — | US | disclosed |
| US-20130244962-A1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES | MERCK FROSST CANADA LTD. (CA) | 2013-09-19 | — | — | US | disclosed |
| US-20100305056-A1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASE | MERCK FROSST CANADA LTD. (CA) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305056-A1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASE | CTSL, SERPINB1, CTSZ | CTSB 24/4885CTSK 46/4885CTSL 1/4885 |
| US-20130244962-A1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES | CTSL, SERPINB1, CTSZ | CTSB 35/4885CTSK 57/4885CTSL 1/4885 |
| US-20200385341-A1 | CATHEPSIN INHIBITORS | CTSK, CTSZ, CTSF | CTSB 5/4885CTSK 1/4885CTSL 12/4885 |
| US-11174224-B2 | Cathepsin inhibitors | CTSK, CTSZ, CTSF | CTSB 5/4885CTSK 1/4885CTSL 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.