Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 4/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946551 | 0.88 | CDK1 (0.41) | DHFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL2946546 | 0.88 | PI4KA (0.37) | HRH4DHFRPI4KAPI4K2BPI4K2A | |
| SCHEMBL2951937 | 0.88 | DHFR (0.45) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL30399128 | 0.86 | FYN (0.41) | KDM4EHRH4GAAMAPTMAPK1 | |
| SCHEMBL2950165 | 0.82 | TLR7 (0.41) | HRH4PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL2953676 | 0.80 | EGFR (0.39) | HRH4DHFR | |
| SCHEMBL3040612 | 0.78 | PI4KA (0.42) | KDM4ESMN1; SMN2DHFRPI4KAPI4K2B | |
| SCHEMBL2954051 | 0.77 | DHFR (0.44) | MAPTDHFRPI4KAPI4K2BPI4K2A | |
| SCHEMBL2952950 | 0.74 | DHFR (0.43) | DHFRMEN1KMT2A | |
| SCHEMBL2946049 | 0.74 | DHFR (0.42) | SMN1; SMN2GAAMAPTMAPK1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |