Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | ILK | Q13418 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CHKA | P35790 | 2/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | GPR4 | P46093 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PTPRF | P10586 | 2/20 | 0.36 |
| ▸ | PTPRA | P18433 | 2/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2955288 | 0.89 | TLR7 (0.42) | TLR7ILKPTPN1CDK1CCNB1 | |
| SCHEMBL2951209 | 0.82 | KDM4E (0.42) | HRH4CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL2953607 | 0.75 | TLR7 (0.44) | TLR7ILKPTPN1CDK1CCNB1 | |
| SCHEMBL2953257 | 0.73 | CDK1 (0.42) | TLR7CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL2952316 | 0.73 | NPC1 (0.51) | — | |
| SCHEMBL2946546 | 0.73 | PI4KA (0.37) | HRH4CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL2946551 | 0.73 | CDK1 (0.41) | CDK1CCNB1CCNE1CDK2PI4KA | |
| SCHEMBL2951937 | 0.72 | DHFR (0.45) | CDK1CCNB1CCNE1CDK2PI4KA | |
| SCHEMBL30399128 | 0.71 | FYN (0.41) | HRH4 | |
| SCHEMBL2946534 | 0.71 | CRHR1 (0.41) | CDK1CCNB1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |