Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 9/20 | 0.36 |
| ▸ | CA2 | P00918 | 9/20 | 0.36 |
| ▸ | MMP1 | P03956 | 9/20 | 0.36 |
| ▸ | MMP2 | P08253 | 9/20 | 0.36 |
| ▸ | MMP9 | P14780 | 9/20 | 0.36 |
| ▸ | MMP8 | P22894 | 9/20 | 0.36 |
| ▸ | MMP13 | P45452 | 9/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | KAT7 | O95251 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5654171 | 0.79 | ABCC9 (0.37) | ABCC9ABCC8KCNJ11KCNJ8CA1 | |
| SCHEMBL8560391 | 0.77 | TDP1 (0.40) | ABCC9ABCC8KCNJ11KCNJ8NAMPT | |
| SCHEMBL2405352 | 0.76 | — | — | |
| SCHEMBL4659266 | 0.75 | ABCC9 (0.40) | ABCC9ABCC8KCNJ11KCNJ8NAMPT | |
| SCHEMBL5657468 | 0.75 | ABCC9 (0.35) | ABCC9ABCC8KCNJ11KCNJ8NAMPT | |
| SCHEMBL6761611 | 0.71 | — | — | |
| SCHEMBL9095381 | 0.71 | NAMPT (0.34) | ABCC9ABCC8KCNJ11KCNJ8NAMPT | |
| SCHEMBL4659111 | 0.68 | ALDH1A1 (0.34) | KAT7KAT6AKAT5KAT8KMT2A | |
| SCHEMBL29227781 | 0.67 | MAPT (0.37) | ABCC9ABCC8KCNJ11KCNJ8NAMPT | |
| SCHEMBL9096607 | 0.65 | ABCC9 (0.32) | ABCC9ABCC8KCNJ11KCNJ8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11304924-B2 | Pharmaceutical compositions comprising nitroxyl donors | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2022-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11304924-B2 | Pharmaceutical compositions comprising nitroxyl donors | TNNT2, TNNI3, NQO1 | ABCC9 343/4885ABCC8 651/4885KCNJ11 3717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.