Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29525564 | 0.80 | CCR2 (0.47) | CES2SRD5A2KDM1AOPRM1OPRL1 | |
| SCHEMBL31378616 | 0.79 | HSD11B1 (0.46) | APPCES2CES1CYP3A4 | |
| SCHEMBL17467926 | 0.77 | AKR1C1 (0.47) | OPRM1OPRL1AKR1C1 | |
| SCHEMBL27037423 | 0.76 | NAPRT (0.40) | CYP3A4CYP1A2 | |
| SCHEMBL17582383 | 0.76 | MEN1 (0.49) | — | |
| SCHEMBL23531198 | 0.76 | MAPT (0.37) | CES2CES1MAOAMAOBCYP1A2 | |
| SCHEMBL29525214 | 0.76 | ALOX15 (0.40) | CES2CES1 | |
| SCHEMBL31687687 | 0.75 | MAOA (0.44) | APPCES2CES1SRD5A2THRB | |
| SCHEMBL19385894 | 0.75 | APP (0.44) | APPCES2CES1SRD5A2THRB | |
| SCHEMBL5085323 | 0.75 | AKR1C1 (0.45) | OPRM1OPRL1AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118146153-A | Synthesis method of bicyclo [1.1.1] pentane-1-acid and amine derivative | 上海泓博智源医药股份有限公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-111094259-B | Analgesic compounds | 里科瑞尔姆IP控股有限责任公司 | 2023-08-11 | — | — | CN | disclosed |
| US-11242327-B2 | Analgesic compounds | RECURIUM IP HOLDINGS, LLC (US) | 2022-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11242327-B2 | Analgesic compounds | INA, IK, ACHE | APP 3553/4885CES2 1537/4885CES1 2476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.