Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 13/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946524 | 0.84 | HRH4 (0.43) | HRH4JAK2JAK1JAK3CHEK1 | |
| SCHEMBL2953250 | 0.81 | CARM1 (0.40) | HRH4ADORA2ACHEK1 | |
| SCHEMBL2953453 | 0.75 | CRHR1 (0.40) | PARP1ADORA2AESR1 | |
| SCHEMBL2952310 | 0.74 | NPC1 (0.50) | HRH4ADORA2A | |
| SCHEMBL2955314 | 0.74 | HRH3 (0.47) | PARP1ADORA2AESR1 | |
| SCHEMBL2950517 | 0.73 | ADORA2A (0.40) | ADORA2ACHEK1 | |
| SCHEMBL2955281 | 0.70 | CAMKK2 (0.45) | PARP1ADORA2AJAK2JAK1JAK3 | |
| SCHEMBL4348402 | 0.68 | HRH3 (0.57) | PARP1ESR1 | |
| SCHEMBL2951931 | 0.68 | PRKDC (0.42) | ADORA2A | |
| SCHEMBL2954446 | 0.67 | TTK (0.37) | PARP1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |