Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.45 |
| ▸ | CHUK | O15111 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | ILK | Q13418 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953601 | 0.85 | PARP1 (0.42) | INSRILKADORA2APARP1CSF1R | |
| SCHEMBL2951931 | 0.82 | PRKDC (0.42) | ADORA2ANPC1TP53MAPK1RAB9A | |
| SCHEMBL2952310 | 0.82 | NPC1 (0.50) | CAMKK2CHUKMAPK8INSRADORA2A | |
| SCHEMBL2953250 | 0.73 | CARM1 (0.40) | ADORA2ATLR7TLR8 | |
| SCHEMBL2946044 | 0.72 | MAPT (0.43) | INSRADORA2AMAPK1SMN1; SMN2 | |
| SCHEMBL2955288 | 0.71 | TLR7 (0.42) | ILKJAK2JAK1TYK2JAK3 | |
| SCHEMBL2952943 | 0.71 | MAP2K7 (0.45) | INSR | |
| SCHEMBL2946549 | 0.70 | CDK1 (0.32) | ADORA2APARP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2946541 | 0.70 | CDK1 (0.41) | ADORA2APARP1 | |
| SCHEMBL2953442 | 0.70 | HRH4 (0.42) | JAK2JAK1JAK3ADORA2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |