Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 6/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | FASN | P49327 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946218 | 0.87 | CHEK1 (0.47) | CARM1TLR9TLR7TLR8CHEK1 | |
| SCHEMBL2946524 | 0.82 | HRH4 (0.43) | CHEK1HRH4 | |
| SCHEMBL2953442 | 0.81 | HRH4 (0.42) | CHEK1HRH4ADORA2A | |
| SCHEMBL2950517 | 0.79 | ADORA2A (0.40) | CARM1CHEK1DRD2ADORA2A | |
| SCHEMBL2955281 | 0.73 | CAMKK2 (0.45) | TLR7TLR8ADORA2A | |
| SCHEMBL2953257 | 0.72 | CDK1 (0.42) | TLR9TLR7TLR8DRD2SLC6A4 | |
| SCHEMBL2951931 | 0.71 | PRKDC (0.42) | DHFRADORA2AADORA1 | |
| SCHEMBL2946339 | 0.70 | CARM1 (0.41) | CARM1TLR9TLR7TLR8CHEK1 | |
| SCHEMBL2946549 | 0.69 | CDK1 (0.32) | HRH4DHFRADORA2AADORA1 | |
| SCHEMBL2946541 | 0.69 | CDK1 (0.41) | DHFRADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |