Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 14/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953442 | 0.84 | HRH4 (0.42) | HRH4CHEK1JAK2JAK1JAK3 | |
| SCHEMBL2953250 | 0.82 | CARM1 (0.40) | HRH4CHEK1 | |
| SCHEMBL2952310 | 0.77 | NPC1 (0.50) | HRH4 | |
| SCHEMBL2946534 | 0.75 | CRHR1 (0.41) | CHEK1CDK2CDK1CCNB1DCPS | |
| SCHEMBL2946218 | 0.74 | CHEK1 (0.47) | CHEK1 | |
| SCHEMBL3701226 | 0.73 | GAA (0.49) | — | |
| SCHEMBL2950517 | 0.70 | ADORA2A (0.40) | CHEK1 | |
| SCHEMBL602176 | 0.70 | HRH4 (0.51) | HRH4 | |
| SCHEMBL2955281 | 0.69 | CAMKK2 (0.45) | JAK2JAK1JAK3 | |
| SCHEMBL18639909 | 0.68 | CHEK1 (0.44) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |