Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | ILK | Q13418 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946044 | 0.86 | MAPT (0.43) | ADORA2AINSRALKCHEK1CDK1 | |
| SCHEMBL2955281 | 0.85 | CAMKK2 (0.45) | PARP1TLR7ADORA2AINSRHTT | |
| SCHEMBL2952943 | 0.76 | MAP2K7 (0.45) | INSRALKCHEK1 | |
| SCHEMBL2953607 | 0.75 | TLR7 (0.44) | PARP1TLR7ADORA2AHTTCDK1 | |
| SCHEMBL2952310 | 0.74 | NPC1 (0.50) | ADORA2AINSRMEN1NPC1RAB9A | |
| SCHEMBL1748552 | 0.73 | SSTR5 (0.48) | MEN1KMT2A | |
| SCHEMBL4764968 | 0.73 | HTT (0.52) | PARP1HTTMEN1NPC1TP53 | |
| SCHEMBL2951931 | 0.72 | PRKDC (0.42) | ADORA2AHTTCDK1CDK2MEN1 | |
| SCHEMBL2946368 | 0.68 | PRKDC (0.40) | ADORA2ACDK1CDK2NPC1TP53 | |
| SCHEMBL6557155 | 0.67 | DHFR (0.54) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |