Pd-217014

Pd-217014

SCHEMBL29539699

COC(=O)C[C@]1(CN)C[C@H]2CC[C@H]2C1

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.35
LMNA P02545 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
CYP1A2 P05177 2/20 0.35
USP2 O75604 1/20 0.35
ALDH1A1 P00352 1/20 0.35
BLM P54132 1/20 0.35
CACNA2D1 P54289 1/20 0.35
TP53 P04637 1/20 0.33
KDM4E B2RXH2 1/20 0.32
HSD17B10 Q99714 1/20 0.30
MGAM O43451 1/20 0.30
GAA P10253 1/20 0.30
SI P14410 1/20 0.30
MGAM2 Q2M2H8 1/20 0.30
EPHX2 P34913 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pd-217014 SCHEMBL8306389 1.00 TSHR (0.35) TSHRLMNASMN1; SMN2CYP1A2USP2
SCHEMBL12021494 0.83 CYP1A2 (0.34) TSHRLMNASMN1; SMN2CYP1A2USP2
SCHEMBL8344819 0.83 CYP1A2 (0.38) LMNACYP1A2ALDH1A1MGAMGAA
SCHEMBL14559622 0.83 CYP1A2 (0.38) LMNACYP1A2ALDH1A1MGAMGAA
SCHEMBL14559637 0.82 CYP1A2 (0.46) TSHRLMNASMN1; SMN2CYP1A2USP2
SCHEMBL16314979 0.79 TSHR (0.50) TSHRLMNASMN1; SMN2CYP1A2USP2
SCHEMBL14559635 0.78 TP53 (0.34) TSHRALDH1A1TP53MGAMGAA
SCHEMBL23355288 0.77 CYP1A2 (0.53) TSHRLMNASMN1; SMN2CYP1A2USP2
SCHEMBL3152370 0.77 CYP1A2 (0.53) TSHRLMNASMN1; SMN2CYP1A2USP2
SCHEMBL5388086 0.77 CYP1A2 (0.53) TSHRLMNASMN1; SMN2CYP1A2USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12578348-B2 Blood indicators of Alzheimer's disease THE INSTITUTE FOR ETHNOMEDICINE (US) 2026-03-17 US claimed
US-20250382671-A1 METHODS OF DETECTION AND ANALYSIS OF NUCLEIC ACID IN CIRCULATING BODILY FLUIDS Brain Chemistry Labs (US) 2025-12-18 US claimed
EP-4287941-A1 BLOOD INDICATORS OF ALZHEIMER'S DISEASE The Institute For Ethnomedicine DBA Brain Chemistry Labs (US) 2023-12-13 EP claimed
EP-4069868-A2 METHODS OF DETECTION AND ANALYSIS OF NUCLEIC ACID IN NEURAL-DERIVED EXOSOMES The Institute For Ethnomedicine DBA Brain Chemistry Labs (US) 2022-10-12 EP claimed
US-20220252620-A1 BLOOD INDICATORS OF ALZHEIMER'S DISEASE The Institute for Ethnomedicine dba Brain Chemistry Labs 2022-08-11 US claimed
WO-2022168006-A1 BLOOD INDICATORS OF ALZHEIMER'S DISEASE The Institute for Ethnomedicine dba Brain Chemistry Labs (US) 2022-08-11 WO claimed
US-20260108484-A1 TREATMENT OF NEUROPATHIC PAIN IN CANINES TRIVIUMVET DESIGNATED ACTIVITY COMPANY (IE) 2026-04-23 US disclosed
US-12578348-B2 Blood indicators of Alzheimer's disease THE INSTITUTE FOR ETHNOMEDICINE (US) 2026-03-17 US disclosed
US-20250382671-A1 METHODS OF DETECTION AND ANALYSIS OF NUCLEIC ACID IN CIRCULATING BODILY FLUIDS Brain Chemistry Labs (US) 2025-12-18 US disclosed
EP-4640276-A2 INHIBITOR OF MNK FOR THE TREATMENT OF NEUROPATHIC PAIN Board Of Regents, The University Of Texas System (US) 2025-10-29 EP disclosed
EP-3972593-B1 INHIBITOR OF MNK FOR THE TREATMENT OF NEUROPATHIC PAIN UNIV TEXAS (US) 2025-07-02 EP disclosed
EP-4287941-A1 BLOOD INDICATORS OF ALZHEIMER'S DISEASE The Institute For Ethnomedicine DBA Brain Chemistry Labs (US) 2023-12-13 EP disclosed
US-20230183232-A1 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS THERAVANCE BIOPHARMA R&D IP LLC (US) 2023-06-15 US disclosed
US-11548887-B2 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists THERAVANCE BIOPHARMA R&D IP, LLC (US) 2023-01-10 US disclosed
EP-4069868-A2 METHODS OF DETECTION AND ANALYSIS OF NUCLEIC ACID IN NEURAL-DERIVED EXOSOMES The Institute For Ethnomedicine DBA Brain Chemistry Labs (US) 2022-10-12 EP disclosed
US-11433081-B2 Compositions and methods for pain management LoMed, Inc. (US) 2022-09-06 US disclosed
US-20220252620-A1 BLOOD INDICATORS OF ALZHEIMER'S DISEASE The Institute for Ethnomedicine dba Brain Chemistry Labs 2022-08-11 US disclosed
WO-2022168006-A1 BLOOD INDICATORS OF ALZHEIMER'S DISEASE The Institute for Ethnomedicine dba Brain Chemistry Labs (US) 2022-08-11 WO disclosed
US-20220226321-A1 INHIBITOR OF MNK FOR THE TREATMENT OF NEUROPATHIC PAIN BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-07-21 US disclosed
EP-3972593-A1 INHIBITOR OF MNK FOR THE TREATMENT OF NEUROPATHIC PAIN Board of Regents, The University of Texas System (US) 2022-03-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260108484-A1 TREATMENT OF NEUROPATHIC PAIN IN CANINES SMN1; SMN2, CACNA1S, CACNA1C TSHR 4465/4885LMNA 469/4885SMN1; SMN2 1/4885
US-20230183232-A1 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS OPRM1, OPRD1, OPRK1 TSHR 331/4885LMNA 4153/4885SMN1; SMN2 1535/4885
US-20220226321-A1 INHIBITOR OF MNK FOR THE TREATMENT OF NEUROPATHIC PAIN NCKAP1, CAMKK2, CAMKK1 TSHR 4847/4885LMNA 4498/4885SMN1; SMN2 65/4885
US-12578348-B2 Blood indicators of Alzheimer's disease COMT, MAOB, ACHE TSHR 3435/4885LMNA 1097/4885SMN1; SMN2 1717/4885
US-11548887-B2 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists OPRM1, OPRD1, OPRK1 TSHR 331/4885LMNA 4153/4885SMN1; SMN2 1535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.